Histone deacetylase 3 represses cholesterol efflux during CD4(+) T-cell activation

After antigenic activation, quiescent naive CD4(+) T cells alter their metabolism to proliferate. This metabolic shift increases production of nucleotides, amino acids, fatty acids, and sterols. Here, we show that histone deacetylase 3 (HDAC3) is critical for activation of murine peripheral CD4(+) T...

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Detalles Bibliográficos
Autores principales: Wilfahrt, Drew, Philips, Rachael L, Lama, Jyoti, Kizerwetter, Monika, Shapiro, Michael Jeremy, McCue, Shaylene A, Kennedy, Madeleine M, Rajcula, Matthew J, Zeng, Hu, Shapiro, Virginia Smith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639145/
https://www.ncbi.nlm.nih.gov/pubmed/34854376
http://dx.doi.org/10.7554/eLife.70978

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