Determinants of curative resection in incidental gallbladder carcinoma with special reference to timing of referral

BACKGROUNDS/AIMS: Re-resection of incidental gallbladder carcinoma (IGBC) is possible in a select group of patients. However, the optimal timing for re-intervention lacks consensus. METHODS: A retrospective analysis was performed for a prospective database of 91 patients with IGBC managed from 2009 to 2018. Patients were divided into three groups based on the duration between the index cholecystectomy and re-operation or final staging: Early (E), < 4 weeks; Intermediate (I), > 4 weeks and < 12 weeks; and Late (L), > 12 weeks. Demographic data, tumor characteristics, and operative details of patients were analyzed to determine factors affecting the re-resectability of IGBC. RESULTS: Twenty-two patients in &lsquo;E&rsquo;, 48 in &lsquo;I&rsquo;, and 21 in &lsquo;L&rsquo; groups were evenly matched. Nearly two thirds were asymptomatic. Curative resection was possible in 48 (52.7%) patients. Metastasis was detected during staging laparoscopy (SL)/laparotomy in 26 (28.6%) patients. The yield of SL was more in the &lsquo;L&rsquo; group (30.8%) than in the &lsquo;I&rsquo; (11.1%) or &lsquo;E&rsquo; (nil) group, avoiding unnecessary laparotomy in 13.6%. Only 28.5% of patients in the &lsquo;L&rsquo; group could undergo curative resection (R0/R1 resection), significantly less than that in the &lsquo;E&rsquo; (50.0%) or &lsquo;I&rsquo; group (64.6%) (both p < 0.001). On multivariate analysis, presentation in intermediate period and tumor differentiation increased the chance of curative resection (p < 0.05). CONCLUSIONS: Asymptomatic patients in the &lsquo;I&rsquo; group with well differentiated IGBC have the best chance of obtaining a curative resection.