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Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway
T cell antigen receptor (TCR) and B cell antigen receptor (BCR) signaling are initiated and tightly regulated by Src-family kinases (SFKs). SFKs positively regulate TCR signaling in naïve T cells but have both positive and negative regulatory roles in BCR signaling in naïve B cells. The proper regul...
Autores principales: | Lu, Wen, Skrzypczynska, Katarzyna M., Weiss, Arthur |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639343/ https://www.ncbi.nlm.nih.gov/pubmed/34675079 http://dx.doi.org/10.1073/pnas.2108957118 |
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