The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis

Although it is held that proinflammatory changes precede the onset of breast cancer, the underlying mechanisms remain obscure. Here, we demonstrate that FRS2β, an adaptor protein expressed in a small subset of epithelial cells, triggers the proinflammatory changes that induce stroma in premalignant...

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Detalles Bibliográficos
Autores principales: Takeuchi, Yasuto, Kimura, Natsuko, Murayama, Takahiko, Machida, Yukino, Iejima, Daisuke, Nishimura, Tatsunori, Terashima, Minoru, Wang, Yuming, Li, Mengjiao, Sakamoto, Reiko, Yamamoto, Mizuki, Itano, Naoki, Inoue, Yusuke, Ito, Masataka, Yoshida, Nobuaki, Inoue, Jun-ichiro, Akashi, Koichi, Saya, Hideyuki, Fujita, Koji, Kuroda, Masahiko, Kitabayashi, Issay, Voon, Dominic, Suzuki, Takeshi, Tojo, Arinobu, Gotoh, Noriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639355/
https://www.ncbi.nlm.nih.gov/pubmed/34663724
http://dx.doi.org/10.1073/pnas.2103658118

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