The genetic source tracking of human urinary exosomes

The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the...

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Detalles Bibliográficos
Autores principales: Zhu, Qingfu, Cheng, Liming, Deng, Chunyu, Huang, Liu, Li, Jiaoyuan, Wang, Yong, Li, Meng, Yang, Qinsi, Dong, Xianjun, Su, Jianzhong, Lee, Luke P., Liu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639375/
https://www.ncbi.nlm.nih.gov/pubmed/34663731
http://dx.doi.org/10.1073/pnas.2108876118
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author Zhu, Qingfu
Cheng, Liming
Deng, Chunyu
Huang, Liu
Li, Jiaoyuan
Wang, Yong
Li, Meng
Yang, Qinsi
Dong, Xianjun
Su, Jianzhong
Lee, Luke P.
Liu, Fei
author_facet Zhu, Qingfu
Cheng, Liming
Deng, Chunyu
Huang, Liu
Li, Jiaoyuan
Wang, Yong
Li, Meng
Yang, Qinsi
Dong, Xianjun
Su, Jianzhong
Lee, Luke P.
Liu, Fei
author_sort Zhu, Qingfu
collection PubMed
description The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine.
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spelling pubmed-86393752021-12-12 The genetic source tracking of human urinary exosomes Zhu, Qingfu Cheng, Liming Deng, Chunyu Huang, Liu Li, Jiaoyuan Wang, Yong Li, Meng Yang, Qinsi Dong, Xianjun Su, Jianzhong Lee, Luke P. Liu, Fei Proc Natl Acad Sci U S A Biological Sciences The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine. National Academy of Sciences 2021-10-18 2021-10-26 /pmc/articles/PMC8639375/ /pubmed/34663731 http://dx.doi.org/10.1073/pnas.2108876118 Text en Copyright © 2021 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Zhu, Qingfu
Cheng, Liming
Deng, Chunyu
Huang, Liu
Li, Jiaoyuan
Wang, Yong
Li, Meng
Yang, Qinsi
Dong, Xianjun
Su, Jianzhong
Lee, Luke P.
Liu, Fei
The genetic source tracking of human urinary exosomes
title The genetic source tracking of human urinary exosomes
title_full The genetic source tracking of human urinary exosomes
title_fullStr The genetic source tracking of human urinary exosomes
title_full_unstemmed The genetic source tracking of human urinary exosomes
title_short The genetic source tracking of human urinary exosomes
title_sort genetic source tracking of human urinary exosomes
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639375/
https://www.ncbi.nlm.nih.gov/pubmed/34663731
http://dx.doi.org/10.1073/pnas.2108876118
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