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Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency
Energy production via the mitochondrial electron transport chain (ETC) and mitophagy are two important processes affected in Parkinson’s disease (PD). Interestingly, PINK1, mutations of which cause early-onset PD, plays a key role in both processes, suggesting that these two mechanisms are connected...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639384/ https://www.ncbi.nlm.nih.gov/pubmed/34686591 http://dx.doi.org/10.1073/pnas.2025347118 |