ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice

Ribosome biogenesis plays a pivotal role in tumorigenesis by supporting robust protein translation. We investigate the functional and molecular mechanism of Zinc finger protein 545 (ZNF545), a transcriptional repressor for ribosomal RNA (rRNA), in colorectal cancer (CRC). ZNF545 was silenced in CRC...

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Detalles Bibliográficos
Autores principales: Wang, Shiyan, Wong, Chi Chun, Zhang, Yanquan, Huang, Junzhe, Li, Chuangen, Zhai, Jianning, Wang, Guoping, Wei, Hong, Zhang, Xueji, He, Housheng Hansen, Yu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639438/
https://www.ncbi.nlm.nih.gov/pubmed/34615997
http://dx.doi.org/10.1038/s41388-021-01938-8

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