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Neuropsychiatric Symptoms Exacerbate the Cognitive Impairments in Patients With Late-Life Depression

Background: Neuropsychiatric symptoms (NPS) and cognitive impairments are both common in patients with late-life depression (LLD). However, the relationship between NPS and cognitive functions in LLD patients remains unclear. The current study aims to explore the effects of NPS on cognitive impairme...

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Autores principales: Zhang, Min, Chen, Ben, Zhong, Xiaomei, Zhou, Huarong, Wang, Qiang, Mai, Naikeng, Wu, Zhangying, Chen, Xinru, Peng, Qi, Zhang, Si, Yang, Minfeng, Lin, Gaohong, Ning, Yuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639522/
https://www.ncbi.nlm.nih.gov/pubmed/34867543
http://dx.doi.org/10.3389/fpsyt.2021.757003
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author Zhang, Min
Chen, Ben
Zhong, Xiaomei
Zhou, Huarong
Wang, Qiang
Mai, Naikeng
Wu, Zhangying
Chen, Xinru
Peng, Qi
Zhang, Si
Yang, Minfeng
Lin, Gaohong
Ning, Yuping
author_facet Zhang, Min
Chen, Ben
Zhong, Xiaomei
Zhou, Huarong
Wang, Qiang
Mai, Naikeng
Wu, Zhangying
Chen, Xinru
Peng, Qi
Zhang, Si
Yang, Minfeng
Lin, Gaohong
Ning, Yuping
author_sort Zhang, Min
collection PubMed
description Background: Neuropsychiatric symptoms (NPS) and cognitive impairments are both common in patients with late-life depression (LLD). However, the relationship between NPS and cognitive functions in LLD patients remains unclear. The current study aims to explore the effects of NPS on cognitive impairments in LLD patients. Methods: Two hundred and sixty-two LLD patients and 141 normal controls (NC) were recruited. Exploratory factor analysis was used to extract factors from the Neuropsychiatric Inventory (NPI). Correlation, mediation, and moderation analyses were used to explore whether NPS exacerbated the cognitive impairments in LLD and whether NPS exhibited different effects on cognitive impairments in acute-state LLD (aLLD) and recovery-state LLD (rLLD). Results: Three main factors were extracted from the NPI, including emotional, behavioral, and psychotic factors. The patients with LLD exhibited worse cognition and higher NPI scores, and the scores of NPI-total and three extracted factors were negatively associated with cognitive scores. The mediation analyses exhibited that NPI-total and behavioral factor scores increase the difference in cognition scores between LLD and NC groups. The mediation analyses exhibited that behavioral factor score played a greater effect on impairing MMSE in the rLLD group than in the aLLD group. Additionally, behavioral factor score was in a trend to be negatively associated with Mini-Mental State Examination (MMSE) score changes at a one-year follow-up (p = 0.051). Conclusions: NPS, especially behavioral symptoms, exacerbate cognitive impairments in LLD and may contribute to residual cognitive impairment in rLLD patients. Early intervention for behavioral symptoms in LLD patients may be beneficial to their long-term clinical prognosis.
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spelling pubmed-86395222021-12-04 Neuropsychiatric Symptoms Exacerbate the Cognitive Impairments in Patients With Late-Life Depression Zhang, Min Chen, Ben Zhong, Xiaomei Zhou, Huarong Wang, Qiang Mai, Naikeng Wu, Zhangying Chen, Xinru Peng, Qi Zhang, Si Yang, Minfeng Lin, Gaohong Ning, Yuping Front Psychiatry Psychiatry Background: Neuropsychiatric symptoms (NPS) and cognitive impairments are both common in patients with late-life depression (LLD). However, the relationship between NPS and cognitive functions in LLD patients remains unclear. The current study aims to explore the effects of NPS on cognitive impairments in LLD patients. Methods: Two hundred and sixty-two LLD patients and 141 normal controls (NC) were recruited. Exploratory factor analysis was used to extract factors from the Neuropsychiatric Inventory (NPI). Correlation, mediation, and moderation analyses were used to explore whether NPS exacerbated the cognitive impairments in LLD and whether NPS exhibited different effects on cognitive impairments in acute-state LLD (aLLD) and recovery-state LLD (rLLD). Results: Three main factors were extracted from the NPI, including emotional, behavioral, and psychotic factors. The patients with LLD exhibited worse cognition and higher NPI scores, and the scores of NPI-total and three extracted factors were negatively associated with cognitive scores. The mediation analyses exhibited that NPI-total and behavioral factor scores increase the difference in cognition scores between LLD and NC groups. The mediation analyses exhibited that behavioral factor score played a greater effect on impairing MMSE in the rLLD group than in the aLLD group. Additionally, behavioral factor score was in a trend to be negatively associated with Mini-Mental State Examination (MMSE) score changes at a one-year follow-up (p = 0.051). Conclusions: NPS, especially behavioral symptoms, exacerbate cognitive impairments in LLD and may contribute to residual cognitive impairment in rLLD patients. Early intervention for behavioral symptoms in LLD patients may be beneficial to their long-term clinical prognosis. Frontiers Media S.A. 2021-11-19 /pmc/articles/PMC8639522/ /pubmed/34867543 http://dx.doi.org/10.3389/fpsyt.2021.757003 Text en Copyright © 2021 Zhang, Chen, Zhong, Zhou, Wang, Mai, Wu, Chen, Peng, Zhang, Yang, Lin and Ning. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Zhang, Min
Chen, Ben
Zhong, Xiaomei
Zhou, Huarong
Wang, Qiang
Mai, Naikeng
Wu, Zhangying
Chen, Xinru
Peng, Qi
Zhang, Si
Yang, Minfeng
Lin, Gaohong
Ning, Yuping
Neuropsychiatric Symptoms Exacerbate the Cognitive Impairments in Patients With Late-Life Depression
title Neuropsychiatric Symptoms Exacerbate the Cognitive Impairments in Patients With Late-Life Depression
title_full Neuropsychiatric Symptoms Exacerbate the Cognitive Impairments in Patients With Late-Life Depression
title_fullStr Neuropsychiatric Symptoms Exacerbate the Cognitive Impairments in Patients With Late-Life Depression
title_full_unstemmed Neuropsychiatric Symptoms Exacerbate the Cognitive Impairments in Patients With Late-Life Depression
title_short Neuropsychiatric Symptoms Exacerbate the Cognitive Impairments in Patients With Late-Life Depression
title_sort neuropsychiatric symptoms exacerbate the cognitive impairments in patients with late-life depression
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639522/
https://www.ncbi.nlm.nih.gov/pubmed/34867543
http://dx.doi.org/10.3389/fpsyt.2021.757003
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