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Novel Effects of Combination Therapy Through Inhibition of Caspase-1/Gasdermin D Induced-Pyroptosis in Lupus Nephritis

OBJECTIVES: Combination therapy with mycophenolate mofetil, tacrolimus and steroids are effective in achieving complete remission in lupus nephritis (LN). Combination therapy uniquely downregulated caspase-1 compared with monotherapies, which can cleave gasdermin D (GSDMD) and was recently identifie...

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Detalles Bibliográficos
Autores principales:	Cao, Heng, Liang, Junyu, Liu, Jing, He, Ye, Ke, Yini, Sun, Yiduo, Jiang, Song, Lin, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639704/ https://www.ncbi.nlm.nih.gov/pubmed/34867948 http://dx.doi.org/10.3389/fimmu.2021.720877

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