The role of exosomal lncRNAs in cancer biology and clinical management

Exosomes play a vital role in cell–cell communication within the cancer microenvironment. Exosomal long noncoding RNAs (lncRNAs) are important regulators in cancer development and are involved in multiple processes, including cancer cell proliferation, angiogenesis, metastasis, drug resistance, and...

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Autores principales: Zhang, Wuwen, Wang, Qinshi, Yang, Yi, Zhou, Siyuan, Zhang, Ping, Feng, Tongbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639705/
https://www.ncbi.nlm.nih.gov/pubmed/34819615
http://dx.doi.org/10.1038/s12276-021-00699-4
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author Zhang, Wuwen
Wang, Qinshi
Yang, Yi
Zhou, Siyuan
Zhang, Ping
Feng, Tongbao
author_facet Zhang, Wuwen
Wang, Qinshi
Yang, Yi
Zhou, Siyuan
Zhang, Ping
Feng, Tongbao
author_sort Zhang, Wuwen
collection PubMed
description Exosomes play a vital role in cell–cell communication within the cancer microenvironment. Exosomal long noncoding RNAs (lncRNAs) are important regulators in cancer development and are involved in multiple processes, including cancer cell proliferation, angiogenesis, metastasis, drug resistance, and immunomodulation. Changes in the levels of exosomal lncRNAs often appear with the occurrence and development of cancer. Therefore, exosomal lncRNAs can be used as biomarkers for cancer diagnosis and prognosis. Exosomal lncRNAs can also indicate the treatment response of patients receiving chemotherapy. Moreover, exosomal lncRNAs are potential therapeutic targets for cancer treatment. In this review, we summarize the role of exosomal lncRNAs in cancer biology as well as in clinical management. A more comprehensive and in-depth understanding of the role of exosomal lncRNAs in cancer may help us better understand the mechanism of cancer development and clinically manage cancer patients.
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spelling pubmed-86397052021-12-10 The role of exosomal lncRNAs in cancer biology and clinical management Zhang, Wuwen Wang, Qinshi Yang, Yi Zhou, Siyuan Zhang, Ping Feng, Tongbao Exp Mol Med Review Article Exosomes play a vital role in cell–cell communication within the cancer microenvironment. Exosomal long noncoding RNAs (lncRNAs) are important regulators in cancer development and are involved in multiple processes, including cancer cell proliferation, angiogenesis, metastasis, drug resistance, and immunomodulation. Changes in the levels of exosomal lncRNAs often appear with the occurrence and development of cancer. Therefore, exosomal lncRNAs can be used as biomarkers for cancer diagnosis and prognosis. Exosomal lncRNAs can also indicate the treatment response of patients receiving chemotherapy. Moreover, exosomal lncRNAs are potential therapeutic targets for cancer treatment. In this review, we summarize the role of exosomal lncRNAs in cancer biology as well as in clinical management. A more comprehensive and in-depth understanding of the role of exosomal lncRNAs in cancer may help us better understand the mechanism of cancer development and clinically manage cancer patients. Nature Publishing Group UK 2021-11-24 /pmc/articles/PMC8639705/ /pubmed/34819615 http://dx.doi.org/10.1038/s12276-021-00699-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Zhang, Wuwen
Wang, Qinshi
Yang, Yi
Zhou, Siyuan
Zhang, Ping
Feng, Tongbao
The role of exosomal lncRNAs in cancer biology and clinical management
title The role of exosomal lncRNAs in cancer biology and clinical management
title_full The role of exosomal lncRNAs in cancer biology and clinical management
title_fullStr The role of exosomal lncRNAs in cancer biology and clinical management
title_full_unstemmed The role of exosomal lncRNAs in cancer biology and clinical management
title_short The role of exosomal lncRNAs in cancer biology and clinical management
title_sort role of exosomal lncrnas in cancer biology and clinical management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639705/
https://www.ncbi.nlm.nih.gov/pubmed/34819615
http://dx.doi.org/10.1038/s12276-021-00699-4
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