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Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia

Cerebral blood flow (CBF) measured with arterial spin labelling (ASL) magnetic resonance imaging (MRI) reflects cerebral perfusion, related to metabolism, and arterial transit time (ATT), related to vascular health. Our aim was to investigate the spatial coefficient of variation (sCoV) of CBF maps a...

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Autores principales: Morgan, Catherine A., Melzer, Tracy R., Roberts, Reece P., Wiebels, Kristina, Mutsaerts, Henk J. M. M., Spriggs, Meg J., Dalrymple-Alford, John C., Anderson, Tim J., Cutfield, Nicholas J., Deib, Gerard, Pfeuffer, Josef, Addis, Donna Rose, Kirk, Ian J., Tippett, Lynette J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639710/
https://www.ncbi.nlm.nih.gov/pubmed/34857793
http://dx.doi.org/10.1038/s41598-021-02313-z
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author Morgan, Catherine A.
Melzer, Tracy R.
Roberts, Reece P.
Wiebels, Kristina
Mutsaerts, Henk J. M. M.
Spriggs, Meg J.
Dalrymple-Alford, John C.
Anderson, Tim J.
Cutfield, Nicholas J.
Deib, Gerard
Pfeuffer, Josef
Addis, Donna Rose
Kirk, Ian J.
Tippett, Lynette J.
author_facet Morgan, Catherine A.
Melzer, Tracy R.
Roberts, Reece P.
Wiebels, Kristina
Mutsaerts, Henk J. M. M.
Spriggs, Meg J.
Dalrymple-Alford, John C.
Anderson, Tim J.
Cutfield, Nicholas J.
Deib, Gerard
Pfeuffer, Josef
Addis, Donna Rose
Kirk, Ian J.
Tippett, Lynette J.
author_sort Morgan, Catherine A.
collection PubMed
description Cerebral blood flow (CBF) measured with arterial spin labelling (ASL) magnetic resonance imaging (MRI) reflects cerebral perfusion, related to metabolism, and arterial transit time (ATT), related to vascular health. Our aim was to investigate the spatial coefficient of variation (sCoV) of CBF maps as a surrogate for ATT, in volunteers meeting criteria for subjective cognitive decline (SCD), amnestic mild cognitive impairment (MCI) and probable Alzheimer’s dementia (AD). Whole-brain pseudo continuous ASL MRI was performed at 3 T in 122 participants (controls = 20, SCD = 44, MCI = 45 and AD = 13) across three sites in New Zealand. From CBF maps that included all grey matter, sCoV progressively increased across each group with increased cognitive deficit. A similar overall trend was found when examining sCoV solely in the temporal lobe. We conclude that sCoV, a simple to compute imaging metric derived from ASL MRI, is sensitive to varying degrees of cognitive changes and supports the view that vascular health contributes to cognitive decline associated with Alzheimer’s disease.
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spelling pubmed-86397102021-12-06 Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia Morgan, Catherine A. Melzer, Tracy R. Roberts, Reece P. Wiebels, Kristina Mutsaerts, Henk J. M. M. Spriggs, Meg J. Dalrymple-Alford, John C. Anderson, Tim J. Cutfield, Nicholas J. Deib, Gerard Pfeuffer, Josef Addis, Donna Rose Kirk, Ian J. Tippett, Lynette J. Sci Rep Article Cerebral blood flow (CBF) measured with arterial spin labelling (ASL) magnetic resonance imaging (MRI) reflects cerebral perfusion, related to metabolism, and arterial transit time (ATT), related to vascular health. Our aim was to investigate the spatial coefficient of variation (sCoV) of CBF maps as a surrogate for ATT, in volunteers meeting criteria for subjective cognitive decline (SCD), amnestic mild cognitive impairment (MCI) and probable Alzheimer’s dementia (AD). Whole-brain pseudo continuous ASL MRI was performed at 3 T in 122 participants (controls = 20, SCD = 44, MCI = 45 and AD = 13) across three sites in New Zealand. From CBF maps that included all grey matter, sCoV progressively increased across each group with increased cognitive deficit. A similar overall trend was found when examining sCoV solely in the temporal lobe. We conclude that sCoV, a simple to compute imaging metric derived from ASL MRI, is sensitive to varying degrees of cognitive changes and supports the view that vascular health contributes to cognitive decline associated with Alzheimer’s disease. Nature Publishing Group UK 2021-12-02 /pmc/articles/PMC8639710/ /pubmed/34857793 http://dx.doi.org/10.1038/s41598-021-02313-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Morgan, Catherine A.
Melzer, Tracy R.
Roberts, Reece P.
Wiebels, Kristina
Mutsaerts, Henk J. M. M.
Spriggs, Meg J.
Dalrymple-Alford, John C.
Anderson, Tim J.
Cutfield, Nicholas J.
Deib, Gerard
Pfeuffer, Josef
Addis, Donna Rose
Kirk, Ian J.
Tippett, Lynette J.
Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
title Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
title_full Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
title_fullStr Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
title_full_unstemmed Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
title_short Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
title_sort spatial variation of perfusion mri reflects cognitive decline in mild cognitive impairment and early dementia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639710/
https://www.ncbi.nlm.nih.gov/pubmed/34857793
http://dx.doi.org/10.1038/s41598-021-02313-z
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