Integrated RNAi screening identifies the NEDDylation pathway as a synergistic partner of azacytidine in acute myeloid leukemia

Treatment of acute myeloid leukemia (AML) remains challenging and novel targets and synergistic therapies still need to be discovered. We performed a high-throughput RNAi screen in three different AML cell lines and primary human leukemic blasts to identify genes that synergize with common antileuke...

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Detalles Bibliográficos
Autores principales: Klosner, Justine, Agelopoulos, Konstantin, Rohde, Christian, Göllner, Stefanie, Schliemann, Christoph, Berdel, Wolfgang E., Müller-Tidow, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639713/
https://www.ncbi.nlm.nih.gov/pubmed/34857808
http://dx.doi.org/10.1038/s41598-021-02695-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639713/
https://www.ncbi.nlm.nih.gov/pubmed/34857808
http://dx.doi.org/10.1038/s41598-021-02695-0

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