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O-GlcNAcylation in health and neurodegenerative diseases

O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein modification interacts with key cellular pathways involved in transcription, translation, and proteostasis. Although ubiquitous throu...

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Autores principales: Lee, Byeong Eun, Suh, Pann-Ghill, Kim, Jae-Ick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639716/
https://www.ncbi.nlm.nih.gov/pubmed/34837015
http://dx.doi.org/10.1038/s12276-021-00709-5
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author Lee, Byeong Eun
Suh, Pann-Ghill
Kim, Jae-Ick
author_facet Lee, Byeong Eun
Suh, Pann-Ghill
Kim, Jae-Ick
author_sort Lee, Byeong Eun
collection PubMed
description O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein modification interacts with key cellular pathways involved in transcription, translation, and proteostasis. Although ubiquitous throughout the body, O-GlcNAc is particularly abundant in the brain, and various proteins commonly found at synapses are O-GlcNAcylated. Recent studies have demonstrated that the modulation of O-GlcNAc in the brain alters synaptic and neuronal functions. Furthermore, altered brain O-GlcNAcylation is associated with either the etiology or pathology of numerous neurodegenerative diseases, while the manipulation of O-GlcNAc exerts neuroprotective effects against these diseases. Although the detailed molecular mechanisms underlying the functional roles of O-GlcNAcylation in the brain remain unclear, O-GlcNAcylation is critical for regulating diverse neural functions, and its levels change during normal and pathological aging. In this review, we will highlight the functional importance of O-GlcNAcylation in the brain and neurodegenerative diseases.
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spelling pubmed-86397162021-12-10 O-GlcNAcylation in health and neurodegenerative diseases Lee, Byeong Eun Suh, Pann-Ghill Kim, Jae-Ick Exp Mol Med Review Article O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein modification interacts with key cellular pathways involved in transcription, translation, and proteostasis. Although ubiquitous throughout the body, O-GlcNAc is particularly abundant in the brain, and various proteins commonly found at synapses are O-GlcNAcylated. Recent studies have demonstrated that the modulation of O-GlcNAc in the brain alters synaptic and neuronal functions. Furthermore, altered brain O-GlcNAcylation is associated with either the etiology or pathology of numerous neurodegenerative diseases, while the manipulation of O-GlcNAc exerts neuroprotective effects against these diseases. Although the detailed molecular mechanisms underlying the functional roles of O-GlcNAcylation in the brain remain unclear, O-GlcNAcylation is critical for regulating diverse neural functions, and its levels change during normal and pathological aging. In this review, we will highlight the functional importance of O-GlcNAcylation in the brain and neurodegenerative diseases. Nature Publishing Group UK 2021-11-26 /pmc/articles/PMC8639716/ /pubmed/34837015 http://dx.doi.org/10.1038/s12276-021-00709-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Lee, Byeong Eun
Suh, Pann-Ghill
Kim, Jae-Ick
O-GlcNAcylation in health and neurodegenerative diseases
title O-GlcNAcylation in health and neurodegenerative diseases
title_full O-GlcNAcylation in health and neurodegenerative diseases
title_fullStr O-GlcNAcylation in health and neurodegenerative diseases
title_full_unstemmed O-GlcNAcylation in health and neurodegenerative diseases
title_short O-GlcNAcylation in health and neurodegenerative diseases
title_sort o-glcnacylation in health and neurodegenerative diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639716/
https://www.ncbi.nlm.nih.gov/pubmed/34837015
http://dx.doi.org/10.1038/s12276-021-00709-5
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