The cytosolic iron–sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors

The relationship between ATR/Chk1 activity and replication stress, coupled with the development of potent and tolerable inhibitors of this pathway, has led to the clinical exploration of ATR and Chk1 inhibitors (ATRi/Chk1i) as anticancer therapies for single-agent or combinatorial application. The c...

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Detalles Bibliográficos
Autores principales: Redwood, Abena B., Zhang, Xiaomei, Seth, Sahil B., Ge, Zhongqi, Bindeman, Wendy E., Zhou, Xinhui, Sinha, Vidya C., Heffernan, Timothy P., Piwnica-Worms, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639742/
https://www.ncbi.nlm.nih.gov/pubmed/34857765
http://dx.doi.org/10.1038/s41523-021-00353-2

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