NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice

Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 DNA glycosylases affect cognition in mice, while the role of NEIL2 remains un...

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Detalles Bibliográficos
Autores principales: Hildrestrand, Gunn A., Rolseth, Veslemøy, Kunath, Nicolas, Suganthan, Rajikala, Jensen, Vidar, Bugaj, Anna M., Fernandez-Berrocal, Marion S., Sikko, Sunniva B., Vetlesen, Susanne, Kuśnierczyk, Anna, Olsen, Ann-Karin, Gützkow, Kristine B., Rowe, Alexander D., Wang, Wei, Moldestad, Olve, Syrstad, Monica D., Slupphaug, Geir, Eide, Lars, Klungland, Arne, Sætrom, Pål, Luna, Luisa, Ye, Jing, Scheffler, Katja, Bjørås, Magnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639745/
https://www.ncbi.nlm.nih.gov/pubmed/34857879
http://dx.doi.org/10.1038/s42003-021-02864-x

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