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Clinical effects of cervical conization with positive margins in cervical cancer

Radical surgery after cervical conization is a common approach for the treatment of cervical cancer. In some cases, disease progression is observed after positive margins at conization, but the effect of conization on disease progression remains unclear. Thus, the aim of this study was to investigat...

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Autores principales: Nagao, Yukari, Yokoi, Akira, Yoshida, Kosuke, Sumi, Masanori, Yoshihara, Masato, Tamauchi, Satoshi, Ikeda, Yoshiki, Yoshikawa, Nobuhisa, Nishino, Kimihiro, Niimi, Kaoru, Kajiyama, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639761/
https://www.ncbi.nlm.nih.gov/pubmed/34857803
http://dx.doi.org/10.1038/s41598-021-02635-y
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author Nagao, Yukari
Yokoi, Akira
Yoshida, Kosuke
Sumi, Masanori
Yoshihara, Masato
Tamauchi, Satoshi
Ikeda, Yoshiki
Yoshikawa, Nobuhisa
Nishino, Kimihiro
Niimi, Kaoru
Kajiyama, Hiroaki
author_facet Nagao, Yukari
Yokoi, Akira
Yoshida, Kosuke
Sumi, Masanori
Yoshihara, Masato
Tamauchi, Satoshi
Ikeda, Yoshiki
Yoshikawa, Nobuhisa
Nishino, Kimihiro
Niimi, Kaoru
Kajiyama, Hiroaki
author_sort Nagao, Yukari
collection PubMed
description Radical surgery after cervical conization is a common approach for the treatment of cervical cancer. In some cases, disease progression is observed after positive margins at conization, but the effect of conization on disease progression remains unclear. Thus, the aim of this study was to investigate the clinical outcomes of positive margins at conization in cervical cancer. A total of 101 patients who underwent cervical conization before radical hysterectomy and pelvic lymph node dissection were considered eligible by reviewing medical records. The association between the positive margins and patient outcomes, including subsequent lymph node metastasis, was evaluated. The rate of lymphovascular space invasion (LVSI) positivity at radical surgery was significantly higher in patients with positive margins (p = 0.017) than in those with negative margins, although there was no significant difference in the rate of pelvic lymph node metastasis (p = 0.155). Moreover, there was no significant difference in the overall survival or progression-free survival between the two groups (p = 0.332 and 0.200, respectively). A positive margin at conization presented no significant prognostic disadvantage; thus, diagnostic conization is one of the most suitable treatment options for early-stage cervical cancer that is difficult to accurately assess.
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spelling pubmed-86397612021-12-06 Clinical effects of cervical conization with positive margins in cervical cancer Nagao, Yukari Yokoi, Akira Yoshida, Kosuke Sumi, Masanori Yoshihara, Masato Tamauchi, Satoshi Ikeda, Yoshiki Yoshikawa, Nobuhisa Nishino, Kimihiro Niimi, Kaoru Kajiyama, Hiroaki Sci Rep Article Radical surgery after cervical conization is a common approach for the treatment of cervical cancer. In some cases, disease progression is observed after positive margins at conization, but the effect of conization on disease progression remains unclear. Thus, the aim of this study was to investigate the clinical outcomes of positive margins at conization in cervical cancer. A total of 101 patients who underwent cervical conization before radical hysterectomy and pelvic lymph node dissection were considered eligible by reviewing medical records. The association between the positive margins and patient outcomes, including subsequent lymph node metastasis, was evaluated. The rate of lymphovascular space invasion (LVSI) positivity at radical surgery was significantly higher in patients with positive margins (p = 0.017) than in those with negative margins, although there was no significant difference in the rate of pelvic lymph node metastasis (p = 0.155). Moreover, there was no significant difference in the overall survival or progression-free survival between the two groups (p = 0.332 and 0.200, respectively). A positive margin at conization presented no significant prognostic disadvantage; thus, diagnostic conization is one of the most suitable treatment options for early-stage cervical cancer that is difficult to accurately assess. Nature Publishing Group UK 2021-12-02 /pmc/articles/PMC8639761/ /pubmed/34857803 http://dx.doi.org/10.1038/s41598-021-02635-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nagao, Yukari
Yokoi, Akira
Yoshida, Kosuke
Sumi, Masanori
Yoshihara, Masato
Tamauchi, Satoshi
Ikeda, Yoshiki
Yoshikawa, Nobuhisa
Nishino, Kimihiro
Niimi, Kaoru
Kajiyama, Hiroaki
Clinical effects of cervical conization with positive margins in cervical cancer
title Clinical effects of cervical conization with positive margins in cervical cancer
title_full Clinical effects of cervical conization with positive margins in cervical cancer
title_fullStr Clinical effects of cervical conization with positive margins in cervical cancer
title_full_unstemmed Clinical effects of cervical conization with positive margins in cervical cancer
title_short Clinical effects of cervical conization with positive margins in cervical cancer
title_sort clinical effects of cervical conization with positive margins in cervical cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639761/
https://www.ncbi.nlm.nih.gov/pubmed/34857803
http://dx.doi.org/10.1038/s41598-021-02635-y
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