A novel cause of emergent hyperammonemia: Cryptococcal fungemia and meningitis

Among etiologies of hyperammonemic emergencies, infection must be considered in certain clinical contexts, particularly among immunocompromised individuals. Although Cryptococcus neoformans is known to be urease-producing, to our knowledge it has not previously been described as a cause of hyperammo...

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Detalles Bibliográficos
Autores principales: Hannah, William B., Nizialek, Gregory, Dempsey, Katherine J., Armitage, Keith B., McCandless, Shawn E., Konczal, Laura L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639793/
https://www.ncbi.nlm.nih.gov/pubmed/34900596
http://dx.doi.org/10.1016/j.ymgmr.2021.100825
Descripción
Sumario:Among etiologies of hyperammonemic emergencies, infection must be considered in certain clinical contexts, particularly among immunocompromised individuals. Although Cryptococcus neoformans is known to be urease-producing, to our knowledge it has not previously been described as a cause of hyperammonemia in patients. We report an immunocompromised man with acute on chronic kidney disease with hyperammonemic crisis due to Cryptococcal meningitis and fungemia. It is important to be aware of C. neoformans as a possible cause of hyperammonemia.

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