A novel cause of emergent hyperammonemia: Cryptococcal fungemia and meningitis

Among etiologies of hyperammonemic emergencies, infection must be considered in certain clinical contexts, particularly among immunocompromised individuals. Although Cryptococcus neoformans is known to be urease-producing, to our knowledge it has not previously been described as a cause of hyperammo...

Descripción completa

Detalles Bibliográficos
Autores principales: Hannah, William B., Nizialek, Gregory, Dempsey, Katherine J., Armitage, Keith B., McCandless, Shawn E., Konczal, Laura L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639793/
https://www.ncbi.nlm.nih.gov/pubmed/34900596
http://dx.doi.org/10.1016/j.ymgmr.2021.100825
_version_ 1784609209320472576
author Hannah, William B.
Nizialek, Gregory
Dempsey, Katherine J.
Armitage, Keith B.
McCandless, Shawn E.
Konczal, Laura L.
author_facet Hannah, William B.
Nizialek, Gregory
Dempsey, Katherine J.
Armitage, Keith B.
McCandless, Shawn E.
Konczal, Laura L.
author_sort Hannah, William B.
collection PubMed
description Among etiologies of hyperammonemic emergencies, infection must be considered in certain clinical contexts, particularly among immunocompromised individuals. Although Cryptococcus neoformans is known to be urease-producing, to our knowledge it has not previously been described as a cause of hyperammonemia in patients. We report an immunocompromised man with acute on chronic kidney disease with hyperammonemic crisis due to Cryptococcal meningitis and fungemia. It is important to be aware of C. neoformans as a possible cause of hyperammonemia.
format Online
Article
Text
id pubmed-8639793
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-86397932021-12-09 A novel cause of emergent hyperammonemia: Cryptococcal fungemia and meningitis Hannah, William B. Nizialek, Gregory Dempsey, Katherine J. Armitage, Keith B. McCandless, Shawn E. Konczal, Laura L. Mol Genet Metab Rep Case Report Among etiologies of hyperammonemic emergencies, infection must be considered in certain clinical contexts, particularly among immunocompromised individuals. Although Cryptococcus neoformans is known to be urease-producing, to our knowledge it has not previously been described as a cause of hyperammonemia in patients. We report an immunocompromised man with acute on chronic kidney disease with hyperammonemic crisis due to Cryptococcal meningitis and fungemia. It is important to be aware of C. neoformans as a possible cause of hyperammonemia. Elsevier 2021-11-25 /pmc/articles/PMC8639793/ /pubmed/34900596 http://dx.doi.org/10.1016/j.ymgmr.2021.100825 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hannah, William B.
Nizialek, Gregory
Dempsey, Katherine J.
Armitage, Keith B.
McCandless, Shawn E.
Konczal, Laura L.
A novel cause of emergent hyperammonemia: Cryptococcal fungemia and meningitis
title A novel cause of emergent hyperammonemia: Cryptococcal fungemia and meningitis
title_full A novel cause of emergent hyperammonemia: Cryptococcal fungemia and meningitis
title_fullStr A novel cause of emergent hyperammonemia: Cryptococcal fungemia and meningitis
title_full_unstemmed A novel cause of emergent hyperammonemia: Cryptococcal fungemia and meningitis
title_short A novel cause of emergent hyperammonemia: Cryptococcal fungemia and meningitis
title_sort novel cause of emergent hyperammonemia: cryptococcal fungemia and meningitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639793/
https://www.ncbi.nlm.nih.gov/pubmed/34900596
http://dx.doi.org/10.1016/j.ymgmr.2021.100825
work_keys_str_mv AT hannahwilliamb anovelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis
AT nizialekgregory anovelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis
AT dempseykatherinej anovelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis
AT armitagekeithb anovelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis
AT mccandlessshawne anovelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis
AT konczallaural anovelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis
AT hannahwilliamb novelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis
AT nizialekgregory novelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis
AT dempseykatherinej novelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis
AT armitagekeithb novelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis
AT mccandlessshawne novelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis
AT konczallaural novelcauseofemergenthyperammonemiacryptococcalfungemiaandmeningitis

Ejemplares similares