PIAS1 alleviates diabetic peripheral neuropathy through SUMOlation of PPAR-γ and miR-124-induced downregulation of EZH2/STAT3

Diabetic peripheral neuropathy (DPN) is a frequently occurring chronic complication of diabetes. In this study, we aim to explore the regulatory mechanism of protein inhibitor of activated STAT1 (PIAS1) in DPN in terms of autophagy and apoptosis of Schwann cells. The SUMOlation of PPAR-γ by PIAS1 wa...

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Detalles Bibliográficos
Autores principales: Hou, Zixin, Chen, Ji, Yang, Huan, Hu, Xiaoling, Yang, Fengrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639830/
https://www.ncbi.nlm.nih.gov/pubmed/34857740
http://dx.doi.org/10.1038/s41420-021-00765-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639830/
https://www.ncbi.nlm.nih.gov/pubmed/34857740
http://dx.doi.org/10.1038/s41420-021-00765-w

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