Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis

Enhancer activation is essential for cell-type specific gene expression during cellular differentiation, however, how enhancers transition from a hypoacetylated “primed” state to a hyperacetylated-active state is incompletely understood. Here, we show SET domain-containing 5 (SETD5) forms a complex...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsumura, Yoshihiro, Ito, Ryo, Yajima, Ayumu, Yamaguchi, Rei, Tanaka, Toshiya, Kawamura, Takeshi, Magoori, Kenta, Abe, Yohei, Uchida, Aoi, Yoneshiro, Takeshi, Hirakawa, Hiroyuki, Zhang, Ji, Arai, Makoto, Yang, Chaoran, Yang, Ge, Takahashi, Hiroki, Fujihashi, Hitomi, Nakaki, Ryo, Yamamoto, Shogo, Ota, Satoshi, Tsutsumi, Shuichi, Inoue, Shin-ichi, Kimura, Hiroshi, Wada, Youichiro, Kodama, Tatsuhiko, Inagaki, Takeshi, Osborne, Timothy F., Aburatani, Hiroyuki, Node, Koichi, Sakai, Juro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639990/
https://www.ncbi.nlm.nih.gov/pubmed/34857762
http://dx.doi.org/10.1038/s41467-021-27321-5

Ejemplares similares

Ejemplares similares