Cargando…

Atlas of RNA editing events affecting protein expression in aged and Alzheimer’s disease human brain tissue

RNA editing is a feature of RNA maturation resulting in the formation of transcripts whose sequence differs from the genome template. Brain RNA editing may be altered in Alzheimer’s disease (AD). Here, we analyzed data from 1,865 brain samples covering 9 brain regions from 1,074 unrelated subjects o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Yiyi, Dammer, Eric B., Felsky, Daniel, Duong, Duc M., Klein, Hans-Ulrich, White, Charles C., Zhou, Maotian, Logsdon, Benjamin A., McCabe, Cristin, Xu, Jishu, Wang, Minghui, Wingo, Thomas S., Lah, James J., Zhang, Bin, Schneider, Julie, Allen, Mariet, Wang, Xue, Ertekin-Taner, Nilüfer, Seyfried, Nicholas T., Levey, Allan I., Bennett, David A., De Jager, Philip L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640037/ https://www.ncbi.nlm.nih.gov/pubmed/34857756 http://dx.doi.org/10.1038/s41467-021-27204-9

Ejemplares similares

Targeted mass spectrometry to quantify brain-derived cerebrospinal fluid biomarkers in Alzheimer’s disease
por: Zhou, Maotian, et al.
Publicado: (2020)

Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease
por: Dai, Jingting, et al.
Publicado: (2018)

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis
por: Wingo, Aliza P., et al.
Publicado: (2021)

Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age
por: Wingo, Aliza P., et al.
Publicado: (2019)

Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer’s Disease
por: Guo, Qi, et al.
Publicado: (2021)

Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease
por: Donovan, Laura E, et al.
Publicado: (2013)

Correction to: Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer’s disease
por: Donovan, Laura E., et al.
Publicado: (2021)

Brain proteome-wide association study implicates novel proteins in depression pathogenesis
por: Wingo, Thomas S., et al.
Publicado: (2021)

Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer’s Disease
por: Higginbotham, Lenora, et al.
Publicado: (2019)

Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease
por: Li, Hong‐Dong, et al.
Publicado: (2021)

Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome
por: Dammer, Eric B., et al.
Publicado: (2022)

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease
por: Higginbotham, Lenora, et al.
Publicado: (2020)

Differential Phagocytic Properties of CD45(low) Microglia and CD45(high) Brain Mononuclear Phagocytes—Activation and Age-Related Effects
por: Rangaraju, Srikant, et al.
Publicado: (2018)

A proteomic network approach across the ALS‐FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain
por: Umoh, Mfon E, et al.
Publicado: (2017)

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
por: Johnson, Erik C. B., et al.
Publicado: (2018)

Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain
por: Wingo, Aliza P., et al.
Publicado: (2020)

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia
por: Wingo, Thomas S., et al.
Publicado: (2020)

Identification of Conserved Proteomic Networks in Neurodegenerative Dementia
por: Swarup, Vivek, et al.
Publicado: (2020)

Coaggregation of RNA-Binding Proteins in a Model of TDP-43 Proteinopathy with Selective RGG Motif Methylation and a Role for RRM1 Ubiquitination
por: Dammer, Eric B., et al.
Publicado: (2012)

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21
por: Hales, Chadwick M, et al.
Publicado: (2014)

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease
por: Rangaraju, Srikant, et al.
Publicado: (2018)

Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer’s disease
por: Modeste, Erica S., et al.
Publicado: (2023)

Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
por: Ping, Lingyan, et al.
Publicado: (2018)

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation
por: Rangaraju, Srikant, et al.
Publicado: (2017)

TBK1 interacts with tau and enhances neurodegeneration in tauopathy
por: Abreha, Measho H., et al.
Publicado: (2021)

Alternative Approaches in Gene Discovery and Characterization in Alzheimer’s Disease
por: Ertekin-Taner, Nilüfer, et al.
Publicado: (2013)

Brain microRNAs are associated with variation in cognitive trajectory in advanced age
por: Wingo, Aliza P., et al.
Publicado: (2022)

Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level
por: Johnson, Erik C. B., et al.
Publicado: (2022)

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins
por: Rangaraju, Srikant, et al.
Publicado: (2018)

Quantitative Mass Spectrometry Analysis of Cerebrospinal Fluid Protein Biomarkers in Alzheimer’s Disease
por: Watson, Caroline M., et al.
Publicado: (2023)

Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer’s disease
por: Ping, Lingyan, et al.
Publicado: (2020)

Proteomic Network Analysis of Alzheimer’s Disease Cerebrospinal Fluid Reveals Alterations Associated with APOE ε4 Genotype and Atomoxetine Treatment
por: Dammer, Eric B., et al.
Publicado: (2023)

Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease
por: Ertekin-Taner, Nilüfer
Publicado: (2011)

Genetics of Alzheimer disease in the pre- and post-GWAS era
por: Ertekin-Taner, Nilüfer
Publicado: (2010)

A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research
por: De Jager, Philip L., et al.
Publicado: (2018)

Proteomic Analysis of Hippocampal Dentate Granule Cells in Frontotemporal Lobar Degeneration: Application of Laser Capture Technology
por: Gozal, Yair M., et al.
Publicado: (2011)

Proteomics of protein post-translational modifications implicated in neurodegeneration
por: Ren, Ru-Jing, et al.
Publicado: (2014)

Machine Learning Selection of Most Predictive Brain Proteins Suggests Role of Sugar Metabolism in Alzheimer’s Disease
por: Tandon, Raghav, et al.
Publicado: (2023)

Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer’s disease
por: Rayaprolu, Sruti, et al.
Publicado: (2020)

Whole genome sequencing–based copy number variations reveal novel pathways and targets in Alzheimer's disease
por: Ming, Chen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_b60jpiqjr02m97dbcmn50h8sdk