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Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure
Cancellous bone plays an indispensable role in the skeletal system due to its various functions and high porosity. In this work, chitosan and hydroxyapatite nanowires (CS@HAP NWs) hybrid nanostructured scaffolds with suitable mechanical properties, high porosity and a fine porous structure were prep...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640089/ https://www.ncbi.nlm.nih.gov/pubmed/34869241 http://dx.doi.org/10.3389/fchem.2021.798299 |
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author | Xia, He Dong, Lun Hao, Min Wei, Yuan Duan, Jiazhi Chen, Xin Yu, Liyang Li, Haijun Sang, Yuanhua Liu, Hong |
author_facet | Xia, He Dong, Lun Hao, Min Wei, Yuan Duan, Jiazhi Chen, Xin Yu, Liyang Li, Haijun Sang, Yuanhua Liu, Hong |
author_sort | Xia, He |
collection | PubMed |
description | Cancellous bone plays an indispensable role in the skeletal system due to its various functions and high porosity. In this work, chitosan and hydroxyapatite nanowires (CS@HAP NWs) hybrid nanostructured scaffolds with suitable mechanical properties, high porosity and a fine porous structure were prepared to simulate the 3-dimensional structure of cancellous bone. The 3D-hybrid scaffolds promote cell adhesion and the migration of human adipose-derived stem cells (hADSCs) inside the scaffolds. The cavities in the scaffolds provide space for the hADSCs proliferation and differentiation. Moreover, the various contents of HAP and the induced mechanical property changes regulate the differentiation of hADSCs toward osteoblasts. Overall, cellular fate regulation of hADSCs via rationally engineered HAP-based hybrid scaffolds is a facile and effective approach for bone tissue engineering. |
format | Online Article Text |
id | pubmed-8640089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86400892021-12-04 Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure Xia, He Dong, Lun Hao, Min Wei, Yuan Duan, Jiazhi Chen, Xin Yu, Liyang Li, Haijun Sang, Yuanhua Liu, Hong Front Chem Chemistry Cancellous bone plays an indispensable role in the skeletal system due to its various functions and high porosity. In this work, chitosan and hydroxyapatite nanowires (CS@HAP NWs) hybrid nanostructured scaffolds with suitable mechanical properties, high porosity and a fine porous structure were prepared to simulate the 3-dimensional structure of cancellous bone. The 3D-hybrid scaffolds promote cell adhesion and the migration of human adipose-derived stem cells (hADSCs) inside the scaffolds. The cavities in the scaffolds provide space for the hADSCs proliferation and differentiation. Moreover, the various contents of HAP and the induced mechanical property changes regulate the differentiation of hADSCs toward osteoblasts. Overall, cellular fate regulation of hADSCs via rationally engineered HAP-based hybrid scaffolds is a facile and effective approach for bone tissue engineering. Frontiers Media S.A. 2021-11-19 /pmc/articles/PMC8640089/ /pubmed/34869241 http://dx.doi.org/10.3389/fchem.2021.798299 Text en Copyright © 2021 Xia, Dong, Hao, Wei, Duan, Chen, Yu, Li, Sang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Xia, He Dong, Lun Hao, Min Wei, Yuan Duan, Jiazhi Chen, Xin Yu, Liyang Li, Haijun Sang, Yuanhua Liu, Hong Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure |
title | Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure |
title_full | Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure |
title_fullStr | Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure |
title_full_unstemmed | Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure |
title_short | Osteogenic Property Regulation of Stem Cells by a Hydroxyapatite 3D-Hybrid Scaffold With Cancellous Bone Structure |
title_sort | osteogenic property regulation of stem cells by a hydroxyapatite 3d-hybrid scaffold with cancellous bone structure |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640089/ https://www.ncbi.nlm.nih.gov/pubmed/34869241 http://dx.doi.org/10.3389/fchem.2021.798299 |
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