Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15

Phytochemical investigation of Diaporthe foeniculina BZM-15 led to one new γ-butyrolactone derivative, diaportone A (1), one cyclopentenone derivative, diaportone B (3), and one monoterpene derivative, diaportone C (5), along with six known compounds (2, 4, and 6–9). Their structures as well as the...

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Autores principales: Kang, Fenghua, Lu, Xiuxiang, Zhang, Sha, Chen, Dekun, Kuang, Min, Peng, Weiwei, Tan, Jianbing, Xu, Kangping, Zou, Zhenxing, Tan, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640094/
https://www.ncbi.nlm.nih.gov/pubmed/34869205
http://dx.doi.org/10.3389/fchem.2021.755351
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author Kang, Fenghua
Lu, Xiuxiang
Zhang, Sha
Chen, Dekun
Kuang, Min
Peng, Weiwei
Tan, Jianbing
Xu, Kangping
Zou, Zhenxing
Tan, Haibo
author_facet Kang, Fenghua
Lu, Xiuxiang
Zhang, Sha
Chen, Dekun
Kuang, Min
Peng, Weiwei
Tan, Jianbing
Xu, Kangping
Zou, Zhenxing
Tan, Haibo
author_sort Kang, Fenghua
collection PubMed
description Phytochemical investigation of Diaporthe foeniculina BZM-15 led to one new γ-butyrolactone derivative, diaportone A (1), one cyclopentenone derivative, diaportone B (3), and one monoterpene derivative, diaportone C (5), along with six known compounds (2, 4, and 6–9). Their structures as well as the absolute configurations were characterized by means of NMR, HRESIMS, and ECD spectroscopy and quantum chemistry calculation, respectively. Furthermore, all compounds were evaluated for their cytotoxic activity and antibacterial activity, and compounds 7 and 8 displayed significant antiproliferative effects on three human cancer cell lines (SF-268, MCF-7, and HepG2) with IC(50) values ranging from 3.6 to 15.8 μM.
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spelling pubmed-86400942021-12-04 Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15 Kang, Fenghua Lu, Xiuxiang Zhang, Sha Chen, Dekun Kuang, Min Peng, Weiwei Tan, Jianbing Xu, Kangping Zou, Zhenxing Tan, Haibo Front Chem Chemistry Phytochemical investigation of Diaporthe foeniculina BZM-15 led to one new γ-butyrolactone derivative, diaportone A (1), one cyclopentenone derivative, diaportone B (3), and one monoterpene derivative, diaportone C (5), along with six known compounds (2, 4, and 6–9). Their structures as well as the absolute configurations were characterized by means of NMR, HRESIMS, and ECD spectroscopy and quantum chemistry calculation, respectively. Furthermore, all compounds were evaluated for their cytotoxic activity and antibacterial activity, and compounds 7 and 8 displayed significant antiproliferative effects on three human cancer cell lines (SF-268, MCF-7, and HepG2) with IC(50) values ranging from 3.6 to 15.8 μM. Frontiers Media S.A. 2021-11-19 /pmc/articles/PMC8640094/ /pubmed/34869205 http://dx.doi.org/10.3389/fchem.2021.755351 Text en Copyright © 2021 Kang, Lu, Zhang, Chen, Kuang, Peng, Tan, Xu, Zou and Tan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Kang, Fenghua
Lu, Xiuxiang
Zhang, Sha
Chen, Dekun
Kuang, Min
Peng, Weiwei
Tan, Jianbing
Xu, Kangping
Zou, Zhenxing
Tan, Haibo
Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
title Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
title_full Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
title_fullStr Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
title_full_unstemmed Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
title_short Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
title_sort diaportones a–c: three new metabolites from endophytic fungus diaporthe foeniculina bzm-15
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640094/
https://www.ncbi.nlm.nih.gov/pubmed/34869205
http://dx.doi.org/10.3389/fchem.2021.755351
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