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Molecular Pathology of Sodium Channel Beta-Subunit Variants

The voltage-gated Na(+) channel regulates the initiation and propagation of the action potential in excitable cells. The major cardiac isoform Na(V)1.5, encoded by SCN5A, comprises a monomer with four homologous repeats (I-IV) that each contain a voltage sensing domain (VSD) and pore domain. In nati...

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Detalles Bibliográficos
Autores principales:	Angsutararux, Paweorn, Zhu, Wandi, Voelker, Taylor L., Silva, Jonathan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640220/ https://www.ncbi.nlm.nih.gov/pubmed/34867379 http://dx.doi.org/10.3389/fphar.2021.761275

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