Cargando…

Molecular Pathology of Sodium Channel Beta-Subunit Variants

The voltage-gated Na(+) channel regulates the initiation and propagation of the action potential in excitable cells. The major cardiac isoform Na(V)1.5, encoded by SCN5A, comprises a monomer with four homologous repeats (I-IV) that each contain a voltage sensing domain (VSD) and pore domain. In nati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Angsutararux, Paweorn, Zhu, Wandi, Voelker, Taylor L., Silva, Jonathan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640220/ https://www.ncbi.nlm.nih.gov/pubmed/34867379 http://dx.doi.org/10.3389/fphar.2021.761275

Ejemplares similares

Conformations of voltage-sensing domain III differentially define Na(V) channel closed- and open-state inactivation
por: Angsutararux, Paweorn, et al.
Publicado: (2021)

Modulation of the effects of class Ib antiarrhythmics on cardiac Na(V)1.5-encoded channels by accessory Na(V)β subunits
por: Zhu, Wandi, et al.
Publicado: (2021)

Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors
por: Angsutararux, Paweorn, et al.
Publicado: (2023)

Mechanisms of noncovalent β subunit regulation of Na(V) channel gating
por: Zhu, Wandi, et al.
Publicado: (2017)

On the multiple roles of the voltage gated sodium channel β1 subunit in genetic diseases
por: Baroni, Debora, et al.
Publicado: (2015)

New Insights into Cardiac and Brain Sodium Channels Modulation by Beta Blockers
por: Chahine, Mohamed
Publicado: (2011)

Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress
por: Angsutararux, Paweorn, et al.
Publicado: (2015)

Intersegment Contacts of Potentially Damaging Variants of Cardiac Sodium Channel
por: Korkosh, Vyacheslav S., et al.
Publicado: (2021)

Regulation of Na(+) channel inactivation by the DIII and DIV voltage-sensing domains
por: Hsu, Eric J., et al.
Publicado: (2017)

Na(+) Channel β Subunits: Overachievers of the Ion Channel Family
por: Brackenbury, William J., et al.
Publicado: (2011)

Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain
por: Salvage, Samantha C., et al.
Publicado: (2019)

Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension
por: Hannila-Handelberg, Tuula, et al.
Publicado: (2005)

The R563Q mutation of the epithelial sodium channel beta-subunit is associated with hypertension
por: Jones, Erika SW, et al.
Publicado: (2011)

Arrhythmia-associated calmodulin variants interact with KCNQ1 to confer aberrant membrane trafficking and function
por: Kang, Po wei, et al.
Publicado: (2023)

Sodium Channels as Targets for Volatile Anesthetics
por: Herold, Karl F., et al.
Publicado: (2012)

Fenestropathy of Voltage-Gated Sodium Channels
por: Gamal El-Din, Tamer M., et al.
Publicado: (2022)

Novel Sodium Channel Inhibitor From Leeches
por: Wang, Gan, et al.
Publicado: (2018)

Structural Advances in Voltage-Gated Sodium Channels
por: Jiang, Daohua, et al.
Publicado: (2022)

Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits
por: Sun, Xiaohui, et al.
Publicado: (2012)

Hyper-O-GlcNAcylation induces cisplatin resistance via regulation of p53 and c-Myc in human lung carcinoma
por: Luanpitpong, Sudjit, et al.
Publicado: (2017)

Propranolol Blocks Cardiac and Neuronal Voltage-Gated Sodium Channels
por: Wang, Dao W., et al.
Publicado: (2010)

Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels
por: Stevens, Marijke, et al.
Publicado: (2011)

The Sodium Channel as a Target for Local Anesthetic Drugs
por: Fozzard, Harry A., et al.
Publicado: (2011)

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres
por: Carbonara, Roberta, et al.
Publicado: (2015)

Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine
por: Desaphy, Jean-François, et al.
Publicado: (2012)

Recent Developments Regarding Voltage-Gated Sodium Channel Blockers for the Treatment of Inherited and Acquired Neuropathic Pain Syndromes
por: Theile, Jonathan W., et al.
Publicado: (2011)

The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells
por: Doray, Adélaïde, et al.
Publicado: (2021)

Regulatory Role of Voltage-Gated Na(+) Channel β Subunits in Sensory Neurons
por: Chahine, Mohamed, et al.
Publicado: (2011)

Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates
por: Chopra, Sameer S, et al.
Publicado: (2007)

Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel Na(V)1.7
por: Kimball, Ian H., et al.
Publicado: (2023)

Voltage-Gated Sodium Channels: Biophysics, Pharmacology, and Related Channelopathies
por: Savio-Galimberti, Eleonora, et al.
Publicado: (2012)

Voltage-gated sodium channels and cancer: is excitability their primary role?
por: Roger, Sébastien, et al.
Publicado: (2015)

Sodium Channels and Local Anesthetics—Old Friends With New Perspectives
por: Körner, Jannis, et al.
Publicado: (2022)

Mechanism of functional interaction between potassium channel Kv1.3 and sodium channel NavBeta1 subunit
por: Kubota, Tomoya, et al.
Publicado: (2017)

Comparing human iPSC-cardiomyocytes versus HEK293T cells unveils disease-causing effects of Brugada mutation A735V of Na(V)1.5 sodium channels
por: de la Roche, Jeanne, et al.
Publicado: (2019)

The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation
por: Veeraraghavan, Rengasayee, et al.
Publicado: (2018)

A new look at sodium channel β subunits
por: Namadurai, Sivakumar, et al.
Publicado: (2015)

Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
por: Gersbacher, Manuel T, et al.
Publicado: (2010)

Recent advances in voltage-gated sodium channels, their pharmacology, and related diseases
por: Desaphy, Jean-François, et al.
Publicado: (2013)

Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_40jjpsh6b5m6v0cn8385fm8arm