Hypoxia Induces Renal Epithelial Injury and Activates Fibrotic Signaling Through Up-Regulation of Arginase-II

The ureohydrolase, type-II arginase (Arg-II), is a mitochondrial enzyme metabolizing L-arginine into urea and L-ornithine and is highly expressed in renal proximal tubular cells (PTC) and upregulated by renal ischemia. Recent studies reported contradictory results on the role of Arg-II in renal inju...

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Detalles Bibliográficos
Autores principales: Liang, Xiujie, Potenza, Duilio Michele, Brenna, Andrea, Ma, Yiqiong, Ren, Zhilong, Cheng, Xin, Ming, Xiu-Fen, Yang, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640467/
https://www.ncbi.nlm.nih.gov/pubmed/34867480
http://dx.doi.org/10.3389/fphys.2021.773719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640467/
https://www.ncbi.nlm.nih.gov/pubmed/34867480
http://dx.doi.org/10.3389/fphys.2021.773719

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