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B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity
Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease characterized by a diverse cadre of clinical presentations. CLE commonly occurs in patients with systemic lupus erythematosus (SLE), and CLE can also develop in the absence of systemic disease. Although CLE is a complex and h...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640489/ https://www.ncbi.nlm.nih.gov/pubmed/34868043 http://dx.doi.org/10.3389/fimmu.2021.775353 |
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author | Abernathy-Close, Lisa Lazar, Stephanie Stannard, Jasmine Tsoi, Lam C. Eddy, Sean Rizvi, Syed M. Yee, Christine M. Myers, Emily M. Namas, Rajaie Lowe, Lori Reed, Tamra J. Wen, Fei Gudjonsson, Johann E. Kahlenberg, J. Michelle Berthier, Celine C. |
author_facet | Abernathy-Close, Lisa Lazar, Stephanie Stannard, Jasmine Tsoi, Lam C. Eddy, Sean Rizvi, Syed M. Yee, Christine M. Myers, Emily M. Namas, Rajaie Lowe, Lori Reed, Tamra J. Wen, Fei Gudjonsson, Johann E. Kahlenberg, J. Michelle Berthier, Celine C. |
author_sort | Abernathy-Close, Lisa |
collection | PubMed |
description | Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease characterized by a diverse cadre of clinical presentations. CLE commonly occurs in patients with systemic lupus erythematosus (SLE), and CLE can also develop in the absence of systemic disease. Although CLE is a complex and heterogeneous disease, several studies have identified common signaling pathways, including those of type I interferons (IFNs), that play a key role in driving cutaneous inflammation across all CLE subsets. However, discriminating factors that drive different phenotypes of skin lesions remain to be determined. Thus, we sought to understand the skin-associated cellular and transcriptional differences in CLE subsets and how the different types of cutaneous inflammation relate to the presence of systemic lupus disease. In this study, we utilized two distinct cohorts comprising a total of 150 CLE lesional biopsies to compare discoid lupus erythematosus (DLE), subacute cutaneous lupus erythematosus (SCLE), and acute cutaneous lupus erythematosus (ACLE) in patients with and without associated SLE. Using an unbiased approach, we demonstrated a CLE subtype-dependent gradient of B cell enrichment in the skin, with DLE lesions harboring a more dominant skin B cell transcriptional signature and enrichment of B cells on immunostaining compared to ACLE and SCLE. Additionally, we observed a significant increase in B cell signatures in the lesional skin from patients with isolated CLE compared with similar lesions from patients with systemic lupus. This trend was driven primarily by differences in the DLE subgroup. Our work thus shows that skin-associated B cell responses distinguish CLE subtypes in patients with and without associated SLE, suggesting that B cell function in skin may be an important link between cutaneous lupus and systemic disease activity. |
format | Online Article Text |
id | pubmed-8640489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86404892021-12-04 B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity Abernathy-Close, Lisa Lazar, Stephanie Stannard, Jasmine Tsoi, Lam C. Eddy, Sean Rizvi, Syed M. Yee, Christine M. Myers, Emily M. Namas, Rajaie Lowe, Lori Reed, Tamra J. Wen, Fei Gudjonsson, Johann E. Kahlenberg, J. Michelle Berthier, Celine C. Front Immunol Immunology Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease characterized by a diverse cadre of clinical presentations. CLE commonly occurs in patients with systemic lupus erythematosus (SLE), and CLE can also develop in the absence of systemic disease. Although CLE is a complex and heterogeneous disease, several studies have identified common signaling pathways, including those of type I interferons (IFNs), that play a key role in driving cutaneous inflammation across all CLE subsets. However, discriminating factors that drive different phenotypes of skin lesions remain to be determined. Thus, we sought to understand the skin-associated cellular and transcriptional differences in CLE subsets and how the different types of cutaneous inflammation relate to the presence of systemic lupus disease. In this study, we utilized two distinct cohorts comprising a total of 150 CLE lesional biopsies to compare discoid lupus erythematosus (DLE), subacute cutaneous lupus erythematosus (SCLE), and acute cutaneous lupus erythematosus (ACLE) in patients with and without associated SLE. Using an unbiased approach, we demonstrated a CLE subtype-dependent gradient of B cell enrichment in the skin, with DLE lesions harboring a more dominant skin B cell transcriptional signature and enrichment of B cells on immunostaining compared to ACLE and SCLE. Additionally, we observed a significant increase in B cell signatures in the lesional skin from patients with isolated CLE compared with similar lesions from patients with systemic lupus. This trend was driven primarily by differences in the DLE subgroup. Our work thus shows that skin-associated B cell responses distinguish CLE subtypes in patients with and without associated SLE, suggesting that B cell function in skin may be an important link between cutaneous lupus and systemic disease activity. Frontiers Media S.A. 2021-11-19 /pmc/articles/PMC8640489/ /pubmed/34868043 http://dx.doi.org/10.3389/fimmu.2021.775353 Text en Copyright © 2021 Abernathy-Close, Lazar, Stannard, Tsoi, Eddy, Rizvi, Yee, Myers, Namas, Lowe, Reed, Wen, Gudjonsson, Kahlenberg and Berthier https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Abernathy-Close, Lisa Lazar, Stephanie Stannard, Jasmine Tsoi, Lam C. Eddy, Sean Rizvi, Syed M. Yee, Christine M. Myers, Emily M. Namas, Rajaie Lowe, Lori Reed, Tamra J. Wen, Fei Gudjonsson, Johann E. Kahlenberg, J. Michelle Berthier, Celine C. B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity |
title | B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity |
title_full | B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity |
title_fullStr | B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity |
title_full_unstemmed | B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity |
title_short | B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity |
title_sort | b cell signatures distinguish cutaneous lupus erythematosus subtypes and the presence of systemic disease activity |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640489/ https://www.ncbi.nlm.nih.gov/pubmed/34868043 http://dx.doi.org/10.3389/fimmu.2021.775353 |
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