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Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus

The analysis of cardiac vibration signals has been shown as an interesting tool for the follow-up of chronic pathologies involving the cardiovascular system, such as heart failure (HF). However, methods to obtain high-quality, real-world and longitudinal data, that do not require the involvement of...

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Autores principales: Areiza-Laverde, Henry, Dopierala, Cindy, Senhadji, Lotfi, Boucher, Francois, Gumery, Pierre Y., Hernández, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640497/
https://www.ncbi.nlm.nih.gov/pubmed/34867453
http://dx.doi.org/10.3389/fphys.2021.748367
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author Areiza-Laverde, Henry
Dopierala, Cindy
Senhadji, Lotfi
Boucher, Francois
Gumery, Pierre Y.
Hernández, Alfredo
author_facet Areiza-Laverde, Henry
Dopierala, Cindy
Senhadji, Lotfi
Boucher, Francois
Gumery, Pierre Y.
Hernández, Alfredo
author_sort Areiza-Laverde, Henry
collection PubMed
description The analysis of cardiac vibration signals has been shown as an interesting tool for the follow-up of chronic pathologies involving the cardiovascular system, such as heart failure (HF). However, methods to obtain high-quality, real-world and longitudinal data, that do not require the involvement of the patient to correctly and regularly acquire these signals, remain to be developed. Implantable systems may be a solution to this observability challenge. In this paper, we evaluate the feasibility of acquiring useful electrocardiographic (ECG) and accelerometry (ACC) data from an innovative implant located in the gastric fundus. In a first phase, we compare data acquired from the gastric fundus with gold standard data acquired from surface sensors on 2 pigs. A second phase investigates the feasibility of deriving useful hemodynamic markers from these gastric signals using data from 4 healthy pigs and 3 pigs with induced HF with longitudinal recordings. The following data processing chain was applied to the recordings: (1) ECG and ACC data denoising, (2) noise-robust real-time QRS detection from ECG signals and cardiac cycle segmentation, (3) Correlation analysis of the cardiac cycles and computation of coherent mean from aligned ECG and ACC, (4) cardiac vibration components segmentation (S1 and S2) from the coherent mean ACC data, and (5) estimation of signal context and a signal-to-noise ratio (SNR) on both signals. Results show a high correlation between the markers acquired from the gastric and thoracic sites, as well as pre-clinical evidence on the feasibility of chronic cardiovascular monitoring from an implantable cardiac device located at the gastric fundus, the main challenge remains on the optimization of the signal-to-noise ratio, in particular for the handling of some sources of noise that are specific to the gastric acquisition site.
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spelling pubmed-86404972021-12-04 Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus Areiza-Laverde, Henry Dopierala, Cindy Senhadji, Lotfi Boucher, Francois Gumery, Pierre Y. Hernández, Alfredo Front Physiol Physiology The analysis of cardiac vibration signals has been shown as an interesting tool for the follow-up of chronic pathologies involving the cardiovascular system, such as heart failure (HF). However, methods to obtain high-quality, real-world and longitudinal data, that do not require the involvement of the patient to correctly and regularly acquire these signals, remain to be developed. Implantable systems may be a solution to this observability challenge. In this paper, we evaluate the feasibility of acquiring useful electrocardiographic (ECG) and accelerometry (ACC) data from an innovative implant located in the gastric fundus. In a first phase, we compare data acquired from the gastric fundus with gold standard data acquired from surface sensors on 2 pigs. A second phase investigates the feasibility of deriving useful hemodynamic markers from these gastric signals using data from 4 healthy pigs and 3 pigs with induced HF with longitudinal recordings. The following data processing chain was applied to the recordings: (1) ECG and ACC data denoising, (2) noise-robust real-time QRS detection from ECG signals and cardiac cycle segmentation, (3) Correlation analysis of the cardiac cycles and computation of coherent mean from aligned ECG and ACC, (4) cardiac vibration components segmentation (S1 and S2) from the coherent mean ACC data, and (5) estimation of signal context and a signal-to-noise ratio (SNR) on both signals. Results show a high correlation between the markers acquired from the gastric and thoracic sites, as well as pre-clinical evidence on the feasibility of chronic cardiovascular monitoring from an implantable cardiac device located at the gastric fundus, the main challenge remains on the optimization of the signal-to-noise ratio, in particular for the handling of some sources of noise that are specific to the gastric acquisition site. Frontiers Media S.A. 2021-11-19 /pmc/articles/PMC8640497/ /pubmed/34867453 http://dx.doi.org/10.3389/fphys.2021.748367 Text en Copyright © 2021 Areiza-Laverde, Dopierala, Senhadji, Boucher, Gumery and Hernández. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Areiza-Laverde, Henry
Dopierala, Cindy
Senhadji, Lotfi
Boucher, Francois
Gumery, Pierre Y.
Hernández, Alfredo
Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
title Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
title_full Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
title_fullStr Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
title_full_unstemmed Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
title_short Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
title_sort analysis of cardiac vibration signals acquired from a novel implant placed on the gastric fundus
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640497/
https://www.ncbi.nlm.nih.gov/pubmed/34867453
http://dx.doi.org/10.3389/fphys.2021.748367
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