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Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals

Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected patients persist into convalescence remains uncle...

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Autores principales: Lim, Jackwee, Puan, Kia Joo, Wang, Liang Wei, Teng, Karen Wei Weng, Loh, Chiew Yee, Tan, Kim Peng, Carissimo, Guillaume, Chan, Yi-Hao, Poh, Chek Meng, Lee, Cheryl Yi-Pin, Fong, Siew-Wai, Yeo, Nicholas Kim-Wah, Chee, Rhonda Sin-Ling, Amrun, Siti Naqiah, Chang, Zi Wei, Tay, Matthew Zirui, Torres-Ruesta, Anthony, Leo Fernandez, Norman, How, Wilson, Andiappan, Anand Kumar, Lee, Wendy, Duan, Kaibo, Tan, Seow-Yen, Yan, Gabriel, Kalimuddin, Shirin, Lye, David Chien, Leo, Yee-Sin, Ong, Sean W. X., Young, Barnaby E., Renia, Laurent, Ng, Lisa F. P., Lee, Bernett, Rötzschke, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640498/
https://www.ncbi.nlm.nih.gov/pubmed/34867943
http://dx.doi.org/10.3389/fimmu.2021.710217
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author Lim, Jackwee
Puan, Kia Joo
Wang, Liang Wei
Teng, Karen Wei Weng
Loh, Chiew Yee
Tan, Kim Peng
Carissimo, Guillaume
Chan, Yi-Hao
Poh, Chek Meng
Lee, Cheryl Yi-Pin
Fong, Siew-Wai
Yeo, Nicholas Kim-Wah
Chee, Rhonda Sin-Ling
Amrun, Siti Naqiah
Chang, Zi Wei
Tay, Matthew Zirui
Torres-Ruesta, Anthony
Leo Fernandez, Norman
How, Wilson
Andiappan, Anand Kumar
Lee, Wendy
Duan, Kaibo
Tan, Seow-Yen
Yan, Gabriel
Kalimuddin, Shirin
Lye, David Chien
Leo, Yee-Sin
Ong, Sean W. X.
Young, Barnaby E.
Renia, Laurent
Ng, Lisa F. P.
Lee, Bernett
Rötzschke, Olaf
author_facet Lim, Jackwee
Puan, Kia Joo
Wang, Liang Wei
Teng, Karen Wei Weng
Loh, Chiew Yee
Tan, Kim Peng
Carissimo, Guillaume
Chan, Yi-Hao
Poh, Chek Meng
Lee, Cheryl Yi-Pin
Fong, Siew-Wai
Yeo, Nicholas Kim-Wah
Chee, Rhonda Sin-Ling
Amrun, Siti Naqiah
Chang, Zi Wei
Tay, Matthew Zirui
Torres-Ruesta, Anthony
Leo Fernandez, Norman
How, Wilson
Andiappan, Anand Kumar
Lee, Wendy
Duan, Kaibo
Tan, Seow-Yen
Yan, Gabriel
Kalimuddin, Shirin
Lye, David Chien
Leo, Yee-Sin
Ong, Sean W. X.
Young, Barnaby E.
Renia, Laurent
Ng, Lisa F. P.
Lee, Bernett
Rötzschke, Olaf
author_sort Lim, Jackwee
collection PubMed
description Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected patients persist into convalescence remains unclear. Herein, comparisons were drawn between the immune responses of COVID-19 infected and convalescent adults. Strikingly, survivors of severe COVID-19 had decreased proportions of NKT and Vδ2 T cells, and increased proportions of low-density neutrophils, IgA+/CD86+/CD123+ non-classical monocytes and hyperactivated HLADR+CD38+ CD8+ T cells, and elevated levels of pro-inflammatory cytokines such as hepatocyte growth factor and vascular endothelial growth factor A, long after virus clearance. Our study suggests potential immune correlates of “long COVID-19”, and defines key cells and cytokines that delineate true and quasi-convalescent states.
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spelling pubmed-86404982021-12-04 Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals Lim, Jackwee Puan, Kia Joo Wang, Liang Wei Teng, Karen Wei Weng Loh, Chiew Yee Tan, Kim Peng Carissimo, Guillaume Chan, Yi-Hao Poh, Chek Meng Lee, Cheryl Yi-Pin Fong, Siew-Wai Yeo, Nicholas Kim-Wah Chee, Rhonda Sin-Ling Amrun, Siti Naqiah Chang, Zi Wei Tay, Matthew Zirui Torres-Ruesta, Anthony Leo Fernandez, Norman How, Wilson Andiappan, Anand Kumar Lee, Wendy Duan, Kaibo Tan, Seow-Yen Yan, Gabriel Kalimuddin, Shirin Lye, David Chien Leo, Yee-Sin Ong, Sean W. X. Young, Barnaby E. Renia, Laurent Ng, Lisa F. P. Lee, Bernett Rötzschke, Olaf Front Immunol Immunology Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected patients persist into convalescence remains unclear. Herein, comparisons were drawn between the immune responses of COVID-19 infected and convalescent adults. Strikingly, survivors of severe COVID-19 had decreased proportions of NKT and Vδ2 T cells, and increased proportions of low-density neutrophils, IgA+/CD86+/CD123+ non-classical monocytes and hyperactivated HLADR+CD38+ CD8+ T cells, and elevated levels of pro-inflammatory cytokines such as hepatocyte growth factor and vascular endothelial growth factor A, long after virus clearance. Our study suggests potential immune correlates of “long COVID-19”, and defines key cells and cytokines that delineate true and quasi-convalescent states. Frontiers Media S.A. 2021-11-19 /pmc/articles/PMC8640498/ /pubmed/34867943 http://dx.doi.org/10.3389/fimmu.2021.710217 Text en Copyright © 2021 Lim, Puan, Wang, Teng, Loh, Tan, Carissimo, Chan, Poh, Lee, Fong, Yeo, Chee, Amrun, Chang, Tay, Torres-Ruesta, Leo Fernandez, How, Andiappan, Lee, Duan, Tan, Yan, Kalimuddin, Lye, Leo, Ong, Young, Renia, Ng, Lee and Rötzschke https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lim, Jackwee
Puan, Kia Joo
Wang, Liang Wei
Teng, Karen Wei Weng
Loh, Chiew Yee
Tan, Kim Peng
Carissimo, Guillaume
Chan, Yi-Hao
Poh, Chek Meng
Lee, Cheryl Yi-Pin
Fong, Siew-Wai
Yeo, Nicholas Kim-Wah
Chee, Rhonda Sin-Ling
Amrun, Siti Naqiah
Chang, Zi Wei
Tay, Matthew Zirui
Torres-Ruesta, Anthony
Leo Fernandez, Norman
How, Wilson
Andiappan, Anand Kumar
Lee, Wendy
Duan, Kaibo
Tan, Seow-Yen
Yan, Gabriel
Kalimuddin, Shirin
Lye, David Chien
Leo, Yee-Sin
Ong, Sean W. X.
Young, Barnaby E.
Renia, Laurent
Ng, Lisa F. P.
Lee, Bernett
Rötzschke, Olaf
Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
title Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
title_full Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
title_fullStr Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
title_full_unstemmed Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
title_short Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
title_sort data-driven analysis of covid-19 reveals persistent immune abnormalities in convalescent severe individuals
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640498/
https://www.ncbi.nlm.nih.gov/pubmed/34867943
http://dx.doi.org/10.3389/fimmu.2021.710217
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