CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab

CCR5 plays a central role in infectious disease, host defense, and cancer progression, thereby making it an ideal target for therapeutic development. Notably, CCR5 is the major HIV entry co-receptor, where its surface density correlates with HIV plasma viremia. The level of CCR5 receptor occupancy (...

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Detalles Bibliográficos
Autores principales: Chang, Xiao L., Wu, Helen L., Webb, Gabriela M., Tiwary, Meenakshi, Hughes, Colette, Reed, Jason S., Hwang, Joseph, Waytashek, Courtney, Boyle, Carla, Pessoa, Cleiton, Sylwester, Andrew W., Morrow, David, Belica, Karina, Fischer, Miranda, Kelly, Scott, Pourhassan, Nader, Bochart, Rachele M., Smedley, Jeremy, Recknor, Christopher P., Hansen, Scott G., Sacha, Jonah B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640501/
https://www.ncbi.nlm.nih.gov/pubmed/34868084
http://dx.doi.org/10.3389/fimmu.2021.794638

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