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HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction

AIMS: Naturally secreted extracellular vesicles (EVs) play important roles in stem-mediated cardioprotection. This study aimed to investigate the cardioprotective function and underlying mechanisms of EVs derived from HIF-1α engineered mesenchymal stem cells (MSCs) in a rat model of AMI. METHODS AND...

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Detalles Bibliográficos
Autores principales:	Wang, Qingjie, Zhang, Le, Sun, Zhiqin, Chi, Boyu, Zou, Ailin, Mao, Lipeng, Xiong, Xu, Jiang, JianGuang, Sun, Ling, Zhu, Wenwu, Ji, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640519/ https://www.ncbi.nlm.nih.gov/pubmed/34901821 http://dx.doi.org/10.1016/j.mtbio.2021.100171

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