The role of GPR56/ADGRG1 in health and disease

GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated...

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Detalles Bibliográficos
Autores principales: Singh, Abhishek Kumar, Lin, Hsi-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chang Gung University 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640549/
https://www.ncbi.nlm.nih.gov/pubmed/34654683
http://dx.doi.org/10.1016/j.bj.2021.04.012
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author Singh, Abhishek Kumar
Lin, Hsi-Hsien
author_facet Singh, Abhishek Kumar
Lin, Hsi-Hsien
author_sort Singh, Abhishek Kumar
collection PubMed
description GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.
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spelling pubmed-86405492021-12-09 The role of GPR56/ADGRG1 in health and disease Singh, Abhishek Kumar Lin, Hsi-Hsien Biomed J Review Article GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease. Chang Gung University 2021-10 2021-05-04 /pmc/articles/PMC8640549/ /pubmed/34654683 http://dx.doi.org/10.1016/j.bj.2021.04.012 Text en © 2021 Chang Gung University. Publishing services by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Singh, Abhishek Kumar
Lin, Hsi-Hsien
The role of GPR56/ADGRG1 in health and disease
title The role of GPR56/ADGRG1 in health and disease
title_full The role of GPR56/ADGRG1 in health and disease
title_fullStr The role of GPR56/ADGRG1 in health and disease
title_full_unstemmed The role of GPR56/ADGRG1 in health and disease
title_short The role of GPR56/ADGRG1 in health and disease
title_sort role of gpr56/adgrg1 in health and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640549/
https://www.ncbi.nlm.nih.gov/pubmed/34654683
http://dx.doi.org/10.1016/j.bj.2021.04.012
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