In-vitro and in-vivo functional observation studies to establish therapeutic potential of alpha-ketoglutarate against methotrexate induced liver injury

BACKGROUND: Methotrexate (MTX) is widely used in chemotherapy but its associated hepatotoxicity is a major complication, limiting its use. This study evaluates possible therapeutic effect of oral alpha-ketoglutarate (AKG) supplementation against MTX-induced hepatotoxicity. METHODS: HepG2 cells were...

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Detalles Bibliográficos
Autores principales: Mehra, Lalita, Bhattacharya, Aditi, Rawat, Harish, Kumar, Amit, Jaimini, Abhinav, Mittal, Gaurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chang Gung University 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640558/
https://www.ncbi.nlm.nih.gov/pubmed/34736875
http://dx.doi.org/10.1016/j.bj.2020.05.012

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