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Comparative hepatotoxicity of a herbicide, epyrifenacil, in humans and rodents by comparing the dynamics and kinetics of its causal metabolite

A new herbicide, epyrifenacil (S-3100), inhibits protoporphyrinogen oxidase (PPO) in plants. Repeated administration of epyrifenacil in laboratory animals led to some toxicological changes related to PPO inhibition, e.g., hepatotoxicity caused by porphyrin accumulation and anemia caused by the inhib...

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Detalles Bibliográficos
Autores principales:	Matsunaga, Kohei, Fukunaga, Satoki, Abe, Jun, Takeuchi, Hayato, Kitamoto, Sachiko, Tomigahara, Yoshitaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pesticide Science Society of Japan 2021
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640676/ https://www.ncbi.nlm.nih.gov/pubmed/34908893 http://dx.doi.org/10.1584/jpestics.D21-026

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