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Pregnancy and weaning regulate human maternal liver size and function
During pregnancy, the rodent liver undergoes hepatocyte proliferation and increases in size, followed by weaning-induced involution via hepatocyte cell death and stromal remodeling, creating a prometastatic niche. These data suggest a mechanism for increased liver metastasis in breast cancer patient...
Autores principales: | Q. Bartlett, Alexandra, Vesco, Kimberly K., Purnell, Jonathan Q., Francisco, Melanie, Goddard, Erica, Guan, Xiangnan, DeBarber, Andrea, Leo, Michael C., Baetscher, Eric, Rooney, William, Naugler, Willscott, Guimaraes, Alexander R., Catalano, Patrick, Xia, Zheng, Schedin, Pepper |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640831/ https://www.ncbi.nlm.nih.gov/pubmed/34815335 http://dx.doi.org/10.1073/pnas.2107269118 |
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