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Nanofat: A therapeutic paradigm in regenerative medicine

Adipose tissue is a compact and well-organized tissue containing a heterogeneous cellular population of progenitor cells, including mesenchymal stromal cells. Due to its availability and accessibility, adipose tissue is considered a “stem cell depot.” Adipose tissue products possess anti-inflammator...

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Autores principales: Jeyaraman, Madhan, Muthu, Sathish, Sharma, Shilpa, Ganta, Charan, Ranjan, Rajni, Jha, Saurabh Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641019/
https://www.ncbi.nlm.nih.gov/pubmed/34909120
http://dx.doi.org/10.4252/wjsc.v13.i11.1733
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author Jeyaraman, Madhan
Muthu, Sathish
Sharma, Shilpa
Ganta, Charan
Ranjan, Rajni
Jha, Saurabh Kumar
author_facet Jeyaraman, Madhan
Muthu, Sathish
Sharma, Shilpa
Ganta, Charan
Ranjan, Rajni
Jha, Saurabh Kumar
author_sort Jeyaraman, Madhan
collection PubMed
description Adipose tissue is a compact and well-organized tissue containing a heterogeneous cellular population of progenitor cells, including mesenchymal stromal cells. Due to its availability and accessibility, adipose tissue is considered a “stem cell depot.” Adipose tissue products possess anti-inflammatory, anti-fibrotic, anti-apoptotic, and immunomodulatory effects. Nanofat, being a compact bundle of stem cells with regenerative and tissue remodeling potential, has potential in translational and regenerative medicine. Considering the wide range of applicability of its reconstructive and regenerative potential, the applications of nanofat can be used in various disciplines. Nanofat behaves on the line of adipose tissue-derived mesenchymal stromal cells. At the site of injury, these stromal cells initiate a site-specific reparative response comprised of remodeling of the extracellular matrix, enhanced and sustained angiogenesis, and immune system modulation. These properties of stromal cells provide a platform for the usage of regenerative medicine principles in curbing various diseases. Details about nanofat, including various preparation methods, characterization, delivery methods, evidence on practical applications, and ethical concerns are included in this review. However, appropriate guidelines and preparation protocols for its optimal use in a wide range of clinical applications have yet to be standardized.
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spelling pubmed-86410192021-12-13 Nanofat: A therapeutic paradigm in regenerative medicine Jeyaraman, Madhan Muthu, Sathish Sharma, Shilpa Ganta, Charan Ranjan, Rajni Jha, Saurabh Kumar World J Stem Cells Review Adipose tissue is a compact and well-organized tissue containing a heterogeneous cellular population of progenitor cells, including mesenchymal stromal cells. Due to its availability and accessibility, adipose tissue is considered a “stem cell depot.” Adipose tissue products possess anti-inflammatory, anti-fibrotic, anti-apoptotic, and immunomodulatory effects. Nanofat, being a compact bundle of stem cells with regenerative and tissue remodeling potential, has potential in translational and regenerative medicine. Considering the wide range of applicability of its reconstructive and regenerative potential, the applications of nanofat can be used in various disciplines. Nanofat behaves on the line of adipose tissue-derived mesenchymal stromal cells. At the site of injury, these stromal cells initiate a site-specific reparative response comprised of remodeling of the extracellular matrix, enhanced and sustained angiogenesis, and immune system modulation. These properties of stromal cells provide a platform for the usage of regenerative medicine principles in curbing various diseases. Details about nanofat, including various preparation methods, characterization, delivery methods, evidence on practical applications, and ethical concerns are included in this review. However, appropriate guidelines and preparation protocols for its optimal use in a wide range of clinical applications have yet to be standardized. Baishideng Publishing Group Inc 2021-11-26 2021-11-26 /pmc/articles/PMC8641019/ /pubmed/34909120 http://dx.doi.org/10.4252/wjsc.v13.i11.1733 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Review
Jeyaraman, Madhan
Muthu, Sathish
Sharma, Shilpa
Ganta, Charan
Ranjan, Rajni
Jha, Saurabh Kumar
Nanofat: A therapeutic paradigm in regenerative medicine
title Nanofat: A therapeutic paradigm in regenerative medicine
title_full Nanofat: A therapeutic paradigm in regenerative medicine
title_fullStr Nanofat: A therapeutic paradigm in regenerative medicine
title_full_unstemmed Nanofat: A therapeutic paradigm in regenerative medicine
title_short Nanofat: A therapeutic paradigm in regenerative medicine
title_sort nanofat: a therapeutic paradigm in regenerative medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641019/
https://www.ncbi.nlm.nih.gov/pubmed/34909120
http://dx.doi.org/10.4252/wjsc.v13.i11.1733
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