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Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice

BACKGROUND: Neuroinflammation is thought to be a cause of Alzheimer’s disease (AD), which is partly caused by inadequate mitophagy. As a receptor of mitophagy, we aimed to reveal the regulatory roles of optineurin (OPTN) on neuroinflammation in the pathogenesis of AD. METHODS: BV2 cells and APP/PS1...

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Detalles Bibliográficos
Autores principales:	Cao, Long-Long, Guan, Pei-Pei, Zhang, Shen-Qing, Yang, Yi, Huang, Xue-Shi, Wang, Pu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641240/ https://www.ncbi.nlm.nih.gov/pubmed/34861878 http://dx.doi.org/10.1186/s12974-021-02327-4

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