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Projections of the Mouse Primary Visual Cortex

Lesion or damage to the primary visual cortex (V1) results in a profound loss of visual perception in humans. Similarly, in mice, optogenetic silencing of V1 profoundly impairs discrimination of orientated gratings. V1 is thought to have such a critical role in perception in part due to its position...

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Autor principal: Resulaj, Arbora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641241/
https://www.ncbi.nlm.nih.gov/pubmed/34867213
http://dx.doi.org/10.3389/fncir.2021.751331
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author Resulaj, Arbora
author_facet Resulaj, Arbora
author_sort Resulaj, Arbora
collection PubMed
description Lesion or damage to the primary visual cortex (V1) results in a profound loss of visual perception in humans. Similarly, in mice, optogenetic silencing of V1 profoundly impairs discrimination of orientated gratings. V1 is thought to have such a critical role in perception in part due to its position in the visual processing hierarchy. It is the first brain area in the neocortex to receive visual input, and it distributes this information to more than 18 brain areas. Here I review recent advances in our understanding of the organization and function of the V1 projections in the mouse. This progress is in part due to new anatomical and viral techniques that allow for efficient labeling of projection neurons. In the final part of the review, I conclude by highlighting challenges and opportunities for future research.
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spelling pubmed-86412412021-12-04 Projections of the Mouse Primary Visual Cortex Resulaj, Arbora Front Neural Circuits Neural Circuits Lesion or damage to the primary visual cortex (V1) results in a profound loss of visual perception in humans. Similarly, in mice, optogenetic silencing of V1 profoundly impairs discrimination of orientated gratings. V1 is thought to have such a critical role in perception in part due to its position in the visual processing hierarchy. It is the first brain area in the neocortex to receive visual input, and it distributes this information to more than 18 brain areas. Here I review recent advances in our understanding of the organization and function of the V1 projections in the mouse. This progress is in part due to new anatomical and viral techniques that allow for efficient labeling of projection neurons. In the final part of the review, I conclude by highlighting challenges and opportunities for future research. Frontiers Media S.A. 2021-11-19 /pmc/articles/PMC8641241/ /pubmed/34867213 http://dx.doi.org/10.3389/fncir.2021.751331 Text en Copyright © 2021 Resulaj. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neural Circuits
Resulaj, Arbora
Projections of the Mouse Primary Visual Cortex
title Projections of the Mouse Primary Visual Cortex
title_full Projections of the Mouse Primary Visual Cortex
title_fullStr Projections of the Mouse Primary Visual Cortex
title_full_unstemmed Projections of the Mouse Primary Visual Cortex
title_short Projections of the Mouse Primary Visual Cortex
title_sort projections of the mouse primary visual cortex
topic Neural Circuits
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641241/
https://www.ncbi.nlm.nih.gov/pubmed/34867213
http://dx.doi.org/10.3389/fncir.2021.751331
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