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DropletQC: improved identification of empty droplets and damaged cells in single-cell RNA-seq data
BACKGROUND: Advances in droplet-based single-cell RNA-sequencing (scRNA-seq) have dramatically increased throughput, allowing tens of thousands of cells to be routinely sequenced in a single experiment. In addition to cells, droplets capture cell-free “ambient” RNA predominantly caused by lysis of c...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641258/ https://www.ncbi.nlm.nih.gov/pubmed/34857027 http://dx.doi.org/10.1186/s13059-021-02547-0 |