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Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice

Remimazolam is a new benzodiazepine of sedative drugs with an ultra-short-acting anesthetic effect, commonly used for critically ill patients (especially septic patients) in intensive care units (ICUs). Although some anesthetics have been reported to show certain anti-inflammatory effects, the role...

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Autores principales: Liu, Xiaolei, Lin, Shaoping, Zhong, Yiyue, Shen, Jiaojiao, Zhang, Xuedi, Luo, Shuhua, Huang, Li, Zhang, Liangqing, Zhou, Shuangnan, Tang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641375/
https://www.ncbi.nlm.nih.gov/pubmed/34867346
http://dx.doi.org/10.3389/fphar.2021.739603
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author Liu, Xiaolei
Lin, Shaoping
Zhong, Yiyue
Shen, Jiaojiao
Zhang, Xuedi
Luo, Shuhua
Huang, Li
Zhang, Liangqing
Zhou, Shuangnan
Tang, Jing
author_facet Liu, Xiaolei
Lin, Shaoping
Zhong, Yiyue
Shen, Jiaojiao
Zhang, Xuedi
Luo, Shuhua
Huang, Li
Zhang, Liangqing
Zhou, Shuangnan
Tang, Jing
author_sort Liu, Xiaolei
collection PubMed
description Remimazolam is a new benzodiazepine of sedative drugs with an ultra-short-acting anesthetic effect, commonly used for critically ill patients (especially septic patients) in intensive care units (ICUs). Although some anesthetics have been reported to show certain anti-inflammatory effects, the role of remimazolam in inflammation is still remained unknown. Here, we studied the effects of remimazolam on macrophage in response to LPS both in vivo and in vitro. Interestingly, compared with LPS treatment group, remimazolam remarkably improved survival rate of endotoxemia mice and decreased the release of LPS-induced inflammatory mediators (such as TNF-α, IL-6, and IL-1β). We further found that remimazolam not only inhibited the activation of MAPK signal pathway at 15 min after LPS treatment but also disturbed Rab5a related TLR4 expression at cell surface in response to LPS at a later time. Such evidence suggests that remimazolam might be beneficial to septic patients who are suffering from uncontrolled inflammatory responses.
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spelling pubmed-86413752021-12-04 Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice Liu, Xiaolei Lin, Shaoping Zhong, Yiyue Shen, Jiaojiao Zhang, Xuedi Luo, Shuhua Huang, Li Zhang, Liangqing Zhou, Shuangnan Tang, Jing Front Pharmacol Pharmacology Remimazolam is a new benzodiazepine of sedative drugs with an ultra-short-acting anesthetic effect, commonly used for critically ill patients (especially septic patients) in intensive care units (ICUs). Although some anesthetics have been reported to show certain anti-inflammatory effects, the role of remimazolam in inflammation is still remained unknown. Here, we studied the effects of remimazolam on macrophage in response to LPS both in vivo and in vitro. Interestingly, compared with LPS treatment group, remimazolam remarkably improved survival rate of endotoxemia mice and decreased the release of LPS-induced inflammatory mediators (such as TNF-α, IL-6, and IL-1β). We further found that remimazolam not only inhibited the activation of MAPK signal pathway at 15 min after LPS treatment but also disturbed Rab5a related TLR4 expression at cell surface in response to LPS at a later time. Such evidence suggests that remimazolam might be beneficial to septic patients who are suffering from uncontrolled inflammatory responses. Frontiers Media S.A. 2021-11-19 /pmc/articles/PMC8641375/ /pubmed/34867346 http://dx.doi.org/10.3389/fphar.2021.739603 Text en Copyright © 2021 Liu, Lin, Zhong, Shen, Zhang, Luo, Huang, Zhang, Zhou and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liu, Xiaolei
Lin, Shaoping
Zhong, Yiyue
Shen, Jiaojiao
Zhang, Xuedi
Luo, Shuhua
Huang, Li
Zhang, Liangqing
Zhou, Shuangnan
Tang, Jing
Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
title Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
title_full Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
title_fullStr Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
title_full_unstemmed Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
title_short Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
title_sort remimazolam protects against lps-induced endotoxicity improving survival of endotoxemia mice
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641375/
https://www.ncbi.nlm.nih.gov/pubmed/34867346
http://dx.doi.org/10.3389/fphar.2021.739603
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