E484K and N501Y SARS-CoV 2 spike mutants Increase ACE2 recognition but reduce affinity for neutralizing antibody

SARS-CoV2 mutants B.1.1.7, B.1.351, and P.1 contain a key mutation N501Y. B.1.135 and P.1 lineages have another mutation, E484K. Here, we decode the effect of these two mutations on the host receptor, ACE2, and neutralizing antibody (B38) recognition. The N501Y RBD mutant binds to ACE2 with higher a...

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Detalles Bibliográficos
Autor principal: Chakraborty, Sandipan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641390/
https://www.ncbi.nlm.nih.gov/pubmed/34915409
http://dx.doi.org/10.1016/j.intimp.2021.108424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641390/
https://www.ncbi.nlm.nih.gov/pubmed/34915409
http://dx.doi.org/10.1016/j.intimp.2021.108424

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