Sigma receptors and neurological disorders

Sigma receptors were identified relatively recently, and their presence has been confirmed in the central nervous system and peripheral organs. Changes in sigma receptor function or expression may be involved in neurological diseases, and thus sigma receptors represent a potential target for treatin...

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Detalles Bibliográficos
Autores principales: Piechal, Agnieszka, Jakimiuk, Alicja, Mirowska-Guzel, Dagmara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641430/
https://www.ncbi.nlm.nih.gov/pubmed/34350561
http://dx.doi.org/10.1007/s43440-021-00310-7
Descripción
Sumario:Sigma receptors were identified relatively recently, and their presence has been confirmed in the central nervous system and peripheral organs. Changes in sigma receptor function or expression may be involved in neurological diseases, and thus sigma receptors represent a potential target for treating central nervous system disorders. Many substances that are ligands for sigma receptors are widely used in therapies for neurological disorders. In the present review, we discuss the roles of sigma receptors, especially in the central nervous system disorders, and related therapies. GRAPHIC ABSTRACT: [Image: see text]

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