Sigma receptors and neurological disorders

Sigma receptors were identified relatively recently, and their presence has been confirmed in the central nervous system and peripheral organs. Changes in sigma receptor function or expression may be involved in neurological diseases, and thus sigma receptors represent a potential target for treatin...

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Detalles Bibliográficos
Autores principales: Piechal, Agnieszka, Jakimiuk, Alicja, Mirowska-Guzel, Dagmara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641430/
https://www.ncbi.nlm.nih.gov/pubmed/34350561
http://dx.doi.org/10.1007/s43440-021-00310-7
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author Piechal, Agnieszka
Jakimiuk, Alicja
Mirowska-Guzel, Dagmara
author_facet Piechal, Agnieszka
Jakimiuk, Alicja
Mirowska-Guzel, Dagmara
author_sort Piechal, Agnieszka
collection PubMed
description Sigma receptors were identified relatively recently, and their presence has been confirmed in the central nervous system and peripheral organs. Changes in sigma receptor function or expression may be involved in neurological diseases, and thus sigma receptors represent a potential target for treating central nervous system disorders. Many substances that are ligands for sigma receptors are widely used in therapies for neurological disorders. In the present review, we discuss the roles of sigma receptors, especially in the central nervous system disorders, and related therapies. GRAPHIC ABSTRACT: [Image: see text]
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spelling pubmed-86414302021-12-17 Sigma receptors and neurological disorders Piechal, Agnieszka Jakimiuk, Alicja Mirowska-Guzel, Dagmara Pharmacol Rep Review Sigma receptors were identified relatively recently, and their presence has been confirmed in the central nervous system and peripheral organs. Changes in sigma receptor function or expression may be involved in neurological diseases, and thus sigma receptors represent a potential target for treating central nervous system disorders. Many substances that are ligands for sigma receptors are widely used in therapies for neurological disorders. In the present review, we discuss the roles of sigma receptors, especially in the central nervous system disorders, and related therapies. GRAPHIC ABSTRACT: [Image: see text] Springer International Publishing 2021-08-05 2021 /pmc/articles/PMC8641430/ /pubmed/34350561 http://dx.doi.org/10.1007/s43440-021-00310-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Piechal, Agnieszka
Jakimiuk, Alicja
Mirowska-Guzel, Dagmara
Sigma receptors and neurological disorders
title Sigma receptors and neurological disorders
title_full Sigma receptors and neurological disorders
title_fullStr Sigma receptors and neurological disorders
title_full_unstemmed Sigma receptors and neurological disorders
title_short Sigma receptors and neurological disorders
title_sort sigma receptors and neurological disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641430/
https://www.ncbi.nlm.nih.gov/pubmed/34350561
http://dx.doi.org/10.1007/s43440-021-00310-7
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