Evolution of plasma vitamin B(12) in patients with solid cancers during curative versus supportive care

INTRODUCTION: The direction of the causal link between solid cancers and elevated plasma vitamin B(12) (B(12)) remains uncertain. METHODS: We retrospectively included patients having two B(12) measurements with a B(12) initially ≥ 1000 ng/l and a solid cancer diagnosed between the measurements. Pati...

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Autores principales: Lacombe, Valentin, Patsouris, Anne, Delattre, Estelle, Lacout, Carole, Urbanski, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641499/
https://www.ncbi.nlm.nih.gov/pubmed/34900064
http://dx.doi.org/10.5114/aoms/140974
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author Lacombe, Valentin
Patsouris, Anne
Delattre, Estelle
Lacout, Carole
Urbanski, Geoffrey
author_facet Lacombe, Valentin
Patsouris, Anne
Delattre, Estelle
Lacout, Carole
Urbanski, Geoffrey
author_sort Lacombe, Valentin
collection PubMed
description INTRODUCTION: The direction of the causal link between solid cancers and elevated plasma vitamin B(12) (B(12)) remains uncertain. METHODS: We retrospectively included patients having two B(12) measurements with a B(12) initially ≥ 1000 ng/l and a solid cancer diagnosed between the measurements. Patients were included in the Curative or Supportive group according to their treatments. RESULTS: B(12) changes over time differed between groups (p = 0.001): +157.4 ng/l/month in the Supportive care group versus –171.6 ng/l/month in the Curative care group. CONCLUSIONS: The decrease of plasma B(12) in cases of curative care could suggest that this B(12) elevation is secondary to solid cancers.
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spelling pubmed-86414992021-12-09 Evolution of plasma vitamin B(12) in patients with solid cancers during curative versus supportive care Lacombe, Valentin Patsouris, Anne Delattre, Estelle Lacout, Carole Urbanski, Geoffrey Arch Med Sci Research Letter INTRODUCTION: The direction of the causal link between solid cancers and elevated plasma vitamin B(12) (B(12)) remains uncertain. METHODS: We retrospectively included patients having two B(12) measurements with a B(12) initially ≥ 1000 ng/l and a solid cancer diagnosed between the measurements. Patients were included in the Curative or Supportive group according to their treatments. RESULTS: B(12) changes over time differed between groups (p = 0.001): +157.4 ng/l/month in the Supportive care group versus –171.6 ng/l/month in the Curative care group. CONCLUSIONS: The decrease of plasma B(12) in cases of curative care could suggest that this B(12) elevation is secondary to solid cancers. Termedia Publishing House 2021-09-03 /pmc/articles/PMC8641499/ /pubmed/34900064 http://dx.doi.org/10.5114/aoms/140974 Text en Copyright: © 2021 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Research Letter
Lacombe, Valentin
Patsouris, Anne
Delattre, Estelle
Lacout, Carole
Urbanski, Geoffrey
Evolution of plasma vitamin B(12) in patients with solid cancers during curative versus supportive care
title Evolution of plasma vitamin B(12) in patients with solid cancers during curative versus supportive care
title_full Evolution of plasma vitamin B(12) in patients with solid cancers during curative versus supportive care
title_fullStr Evolution of plasma vitamin B(12) in patients with solid cancers during curative versus supportive care
title_full_unstemmed Evolution of plasma vitamin B(12) in patients with solid cancers during curative versus supportive care
title_short Evolution of plasma vitamin B(12) in patients with solid cancers during curative versus supportive care
title_sort evolution of plasma vitamin b(12) in patients with solid cancers during curative versus supportive care
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641499/
https://www.ncbi.nlm.nih.gov/pubmed/34900064
http://dx.doi.org/10.5114/aoms/140974
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