Genetic polymorphism of CYP3A4 is associated with poor response to ifosfamide treatment in children with solid embryonic tumors

INTRODUCTION: The CYP450 complex participates in the metabolism of ifosfamide, an antineoplastic drug used to treat solid tumors. CYP450 genes contain several single nucleotide polymorphisms (SNPs) that confer different activity towards the enzyme. The aim of our study was to analyze gene frequencie...

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Detalles Bibliográficos
Autores principales: Espindola, Luz María Torres, López, Manuel De JesÚs Castillejos, Flores, Armando De Uña, Espinosa, Liliana Rivera, Granados, Julio, Pacheco, Juan Luis Chávez, García, Martín Pérez, Cervantes, Ma Teresa Ramos, Méndez, Vilma Carolina Bekker, Doño, Susana Hernández, Ruíz Gómez, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Basic Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641500/
https://www.ncbi.nlm.nih.gov/pubmed/34900058
http://dx.doi.org/10.5114/aoms.2019.86648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641500/
https://www.ncbi.nlm.nih.gov/pubmed/34900058
http://dx.doi.org/10.5114/aoms.2019.86648

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