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Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates

Nearly one-third of proteins are initially targeted to the endoplasmic reticulum (ER) membrane, where they are correctly folded and then delivered to their final cellular destinations. To prevent the accumulation of misfolded membrane proteins, ER-associated degradation (ERAD) moves these clients fr...

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Detalles Bibliográficos
Autores principales:	Nejatfard, Anahita, Wauer, Nicholas, Bhaduri, Satarupa, Conn, Adam, Gourkanti, Saroj, Singh, Narinderbir, Kuo, Tiffany, Kandel, Rachel, Amaro, Rommie E., Neal, Sonya E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641752/ https://www.ncbi.nlm.nih.gov/pubmed/34686332 http://dx.doi.org/10.1016/j.celrep.2021.109840

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