FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

The transcription factor FOXN1 is a master regulator of thymic epithelial cell (TEC) development and function. Here, we demonstrate that FOXN1 expression is differentially regulated during organogenesis and participates in multimolecular nuclear condensates essential for the factor’s transcriptional...

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Detalles Bibliográficos
Autores principales: Rota, Ioanna A., Handel, Adam E., Maio, Stefano, Klein, Fabian, Dhalla, Fatima, Deadman, Mary E., Cheuk, Stanley, Newman, Joseph A., Michaels, Yale S., Zuklys, Saulius, Prevot, Nicolas, Hublitz, Philip, Charles, Philip D., Gkazi, Athina Soragia, Adamopoulou, Eleni, Qasim, Waseem, Davies, Edward Graham, Hanson, Imelda, Pagnamenta, Alistair T., Camps, Carme, Dreau, Helene M., White, Andrea, James, Kieran, Fischer, Roman, Gileadi, Opher, Taylor, Jenny C., Fulga, Tudor, Lagerholm, B. Christoffer, Anderson, Graham, Sezgin, Erdinc, Holländer, Georg A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641933/
https://www.ncbi.nlm.nih.gov/pubmed/34860543
http://dx.doi.org/10.1126/sciadv.abj9247

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