Mitochondrial C1qbp promotes differentiation of effector CD8(+) T cells via metabolic-epigenetic reprogramming

Early-activated CD8(+) T cells increase both aerobic glycolysis and mitochondrial oxidative phosphorylation (OXPHOS). However, whether and how the augmentation of OXPHOS regulates differentiation of effector CD8(+) T cell remains unclear. Here, we found that C1qbp was intrinsically required for such...

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Detalles Bibliográficos
Autores principales: Zhai, Xingyuan, Liu, Kai, Fang, Hongkun, Zhang, Quan, Gao, Xianjun, Liu, Fang, Zhou, Shangshang, Wang, Xinming, Niu, Yujia, Hong, Yazhen, Lin, Shu-Hai, Liu, Wen-Hsien, Xiao, Changchun, Li, Qiyuan, Xiao, Nengming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641941/
https://www.ncbi.nlm.nih.gov/pubmed/34860557
http://dx.doi.org/10.1126/sciadv.abk0490

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