Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation

Many metabolic enzymes self-assemble into micron-scale filaments to organize and regulate metabolism. The appearance of these assemblies often coincides with large metabolic changes as in development, cancer, and stress. Yeast undergo cytoplasmic acidification upon starvation, triggering the assembl...

Descripción completa

Detalles Bibliográficos
Autores principales: Hansen, Jesse M, Horowitz, Avital, Lynch, Eric M, Farrell, Daniel P, Quispe, Joel, DiMaio, Frank, Kollman, Justin M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641951/
https://www.ncbi.nlm.nih.gov/pubmed/34734801
http://dx.doi.org/10.7554/eLife.73368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641951/
https://www.ncbi.nlm.nih.gov/pubmed/34734801
http://dx.doi.org/10.7554/eLife.73368

Ejemplares similares