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Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19
The lungs are the main site that is affected in severe COVID-19, and post-mortem lung tissue provides crucial insights into the pathophysiology of severe disease. From basic histology to state-of-the-art multiparameter digital pathology technologies, post-mortem lung tissue provides snapshots of tis...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641959/ https://www.ncbi.nlm.nih.gov/pubmed/34871544 http://dx.doi.org/10.1016/S2213-2600(21)00408-2 |
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author | Milross, Luke Majo, Joaquim Cooper, Nigel Kaye, Paul M Bayraktar, Omer Filby, Andrew Fisher, Andrew J |
author_facet | Milross, Luke Majo, Joaquim Cooper, Nigel Kaye, Paul M Bayraktar, Omer Filby, Andrew Fisher, Andrew J |
author_sort | Milross, Luke |
collection | PubMed |
description | The lungs are the main site that is affected in severe COVID-19, and post-mortem lung tissue provides crucial insights into the pathophysiology of severe disease. From basic histology to state-of-the-art multiparameter digital pathology technologies, post-mortem lung tissue provides snapshots of tissue architecture, and resident and inflammatory cell phenotypes and composition at the time of death. Contrary to early assumptions that COVID-19 in the lungs is a uniform disease, post-mortem findings have established a high degree of disease heterogeneity. Classic diffuse alveolar damage represents just one phenotype, with disease divisible by early and late progression as well as by pathophysiological process. A distinct lung tissue state occurs with secondary infection; extrapulmonary causes of death might also originate from a pathological process in the lungs linked to microthrombosis. This heterogeneity of COVID-19 lung disease must be recognised in the management of patients and in the development of novel treatment strategies. |
format | Online Article Text |
id | pubmed-8641959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86419592021-12-06 Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19 Milross, Luke Majo, Joaquim Cooper, Nigel Kaye, Paul M Bayraktar, Omer Filby, Andrew Fisher, Andrew J Lancet Respir Med Review The lungs are the main site that is affected in severe COVID-19, and post-mortem lung tissue provides crucial insights into the pathophysiology of severe disease. From basic histology to state-of-the-art multiparameter digital pathology technologies, post-mortem lung tissue provides snapshots of tissue architecture, and resident and inflammatory cell phenotypes and composition at the time of death. Contrary to early assumptions that COVID-19 in the lungs is a uniform disease, post-mortem findings have established a high degree of disease heterogeneity. Classic diffuse alveolar damage represents just one phenotype, with disease divisible by early and late progression as well as by pathophysiological process. A distinct lung tissue state occurs with secondary infection; extrapulmonary causes of death might also originate from a pathological process in the lungs linked to microthrombosis. This heterogeneity of COVID-19 lung disease must be recognised in the management of patients and in the development of novel treatment strategies. Elsevier Ltd. 2022-01 2021-12-03 /pmc/articles/PMC8641959/ /pubmed/34871544 http://dx.doi.org/10.1016/S2213-2600(21)00408-2 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Milross, Luke Majo, Joaquim Cooper, Nigel Kaye, Paul M Bayraktar, Omer Filby, Andrew Fisher, Andrew J Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19 |
title | Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19 |
title_full | Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19 |
title_fullStr | Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19 |
title_full_unstemmed | Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19 |
title_short | Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19 |
title_sort | post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641959/ https://www.ncbi.nlm.nih.gov/pubmed/34871544 http://dx.doi.org/10.1016/S2213-2600(21)00408-2 |
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