A structural view of the SARS-CoV-2 virus and its assembly

The SARS-CoV-2 pandemic that struck in 2019 has left the world crippled with hundreds of millions of cases and millions of people dead. During this time, we have seen unprecedented support and collaboration amongst scientists to respond to this deadly disease. Advances in the field of structural bio...

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Autores principales: Hardenbrook, Nathan J, Zhang, Peijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642146/
https://www.ncbi.nlm.nih.gov/pubmed/34915287
http://dx.doi.org/10.1016/j.coviro.2021.11.011
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author Hardenbrook, Nathan J
Zhang, Peijun
author_facet Hardenbrook, Nathan J
Zhang, Peijun
author_sort Hardenbrook, Nathan J
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description The SARS-CoV-2 pandemic that struck in 2019 has left the world crippled with hundreds of millions of cases and millions of people dead. During this time, we have seen unprecedented support and collaboration amongst scientists to respond to this deadly disease. Advances in the field of structural biology, in particular cryoEM and cryo-electron tomography, have allowed unprecedented structural analysis of SARS-CoV-2. Here, we review the structural work on the SARS-CoV-2 virus and viral components, as well as its cellular assembly process, highlighting some important structural findings that have made significant impact on the protection from and treatment of emerging viral infections.
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spelling pubmed-86421462021-12-06 A structural view of the SARS-CoV-2 virus and its assembly Hardenbrook, Nathan J Zhang, Peijun Curr Opin Virol Article The SARS-CoV-2 pandemic that struck in 2019 has left the world crippled with hundreds of millions of cases and millions of people dead. During this time, we have seen unprecedented support and collaboration amongst scientists to respond to this deadly disease. Advances in the field of structural biology, in particular cryoEM and cryo-electron tomography, have allowed unprecedented structural analysis of SARS-CoV-2. Here, we review the structural work on the SARS-CoV-2 virus and viral components, as well as its cellular assembly process, highlighting some important structural findings that have made significant impact on the protection from and treatment of emerging viral infections. Elsevier 2022-02 /pmc/articles/PMC8642146/ /pubmed/34915287 http://dx.doi.org/10.1016/j.coviro.2021.11.011 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hardenbrook, Nathan J
Zhang, Peijun
A structural view of the SARS-CoV-2 virus and its assembly
title A structural view of the SARS-CoV-2 virus and its assembly
title_full A structural view of the SARS-CoV-2 virus and its assembly
title_fullStr A structural view of the SARS-CoV-2 virus and its assembly
title_full_unstemmed A structural view of the SARS-CoV-2 virus and its assembly
title_short A structural view of the SARS-CoV-2 virus and its assembly
title_sort structural view of the sars-cov-2 virus and its assembly
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642146/
https://www.ncbi.nlm.nih.gov/pubmed/34915287
http://dx.doi.org/10.1016/j.coviro.2021.11.011
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